Evidence map›Paper›PMID 39456148›Full record

ArticleBiomolecules2024

STING Promotes the Progression of ADPKD by Regulating Mitochondrial Function, Inflammation, Fibrosis, and Apoptosis.

Jiao Wu, Shasha Cheng, Geoffray Lee, Ewud Agborbesong, Xiaoyan Li, Xia Zhou, Xiaogang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. The Role of Mitochondria in Polycystic Kidney Disease.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiao WuDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-0053-7479
Shasha ChengDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-0199-7899
Geoffray LeeDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Ewud AgborbesongDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Xiaoyan LiDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Xia ZhouDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Xiaogang LiDepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Funding

Li Xiaogang DOD Focused Program Award: PR221810Li Xiaogang NIH R01 DK126662Li Xiaogang NIH R01 DK129241NIDDK NIH HHS K01 DK107729NIDDK NIH HHS R01 DK126662NIDDK NIH HHS R01 DK129241Zhou Xia NIH K01 DK107729
6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a predominant genetic disease, which is caused by mutations in PKD genes and is associated with DNA damage in cystic cells. The intrinsic stimulator of interferon genes (STING) pathway is crucial for recognizing damaged DNA in the cytosol, triggering the expression of inflammatory cytokines to activate defense mechanisms. However, the precise roles and mechanisms of STING in ADPKD remain elusive. In this study, we show that

Indexed as

ApoptosisFibrosisInflammationMembrane ProteinsMitochondriaPolycystic Kidney, Autosomal DominantAnimalsDisease Models, AnimalDisease ProgressionHumansKidneyMiceMice, Inbred C57BLMice, KnockoutNF-kappa BSignal TransductionMembrane ProteinsNF-kappa BSting1 protein, mouseSTING ProteinTRPP Cation ChannelsADPKDmitochondrialSTING

Identifiers

PMID39456148
PMCPMC11505933

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.