Evidence map›Paper›PMID 39456434›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Different Oxidative Stress and Inflammation Patterns of Diseased Left Anterior Descending Coronary Artery versus Internal Thoracic Artery.

Andrea Salica, Vittoria Cammisotto, Raffaele Scaffa, Giulio Folino, Ruggero De Paulis, Roberto Carnevale, Umberto Benedetto, Wael Saade, Antonino Marullo, Sebastiano Sciarretta and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andrea SalicaDepartment of Cardiac Surgery, European Hospital, 00149 Rome, Italy.
Vittoria CammisottoDepartment of Clinical, Internal Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.ORCID 0000-0003-1966-5945
Raffaele ScaffaDepartment of Cardiac Surgery, European Hospital, 00149 Rome, Italy.ORCID 0000-0002-9048-631X
Giulio FolinoDepartment of Cardiac Surgery, European Hospital, 00149 Rome, Italy.
Ruggero De PaulisDepartment of Cardiac Surgery, European Hospital, 00149 Rome, Italy.
Roberto CarnevaleDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.ORCID 0000-0002-6216-9595
Umberto BenedettoDepartment of Cardiac Surgery, University "G. d'Annunzio", 66013 Pescara, Italy.
Wael SaadeDepartment of Clinical, Internal Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.ORCID 0000-0001-6617-6103
Antonino MarulloDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.ORCID 0000-0003-2565-832X
Sebastiano SciarrettaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.
Gianmarco SartoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.ORCID 0009-0008-2571-2377
Silvia PalmerioIRCCS NeuroMed, 86077 Pozzilli, Italy.ORCID 0000-0001-8874-3711
Valentina ValentiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.ORCID 0000-0002-6755-9648
Mariangela PeruzziDepartment of Clinical, Internal Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.ORCID 0009-0009-7268-5188
Fabio MiraldiDepartment of Clinical, Internal Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, 00161 Rome, Italy.ORCID 0000-0002-2404-3369
Francesco Giosuè IraceDepartment of Cardiac Surgery and Heart Transplantation, San Camillo Forlanini Hospital, Circ.ne Gianicolense 87, 00152 Rome, Italy.ORCID 0000-0002-8879-7012
Giacomo FratiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.ORCID 0000-0003-2703-3761

Funding

European Union PE06-HEAL ITALIA-SPOKE 1-DSBMCSapienza University of Rome AR22117A82F039EA
6 · The paper itself

Abstract

backgroundOxidative stress and inflammation are typically implied in atherosclerosis pathogenesis and progression, especially in coronary artery disease (CAD). Our objective was to investigate the oxidative stress and inflammation burden directly associated with atherosclerotic plaque in patients with stable coronary disease undergoing coronary artery bypass graft (CABG) surgery. Specifically, markers of oxidative stress and inflammation were compared in blood samples obtained from the atherosclerotic left anterior descending artery (LAD) and blood samples obtained from the healthy left internal thoracic artery (LITA), used as a bypass graft, within the same patient.

methodsTwenty patients scheduled for off-pump CABG were enrolled. Blood samples were collected from the LITA below anastomosis and the LAD below the stenosis. Samples were analysed for oxidative stress (sNOXdp, H

resultsThe analysis showed a significant increase in oxidative stress burden in the LAD as compared to LITA, as indicated by higher sNOX2-dp and H

conclusionsThe oxidative stress and inflammatory burden are specifically enhanced in the LAD artery of stable coronary patients compared to systemic blood from the LITA of stable coronary patients.

Indexed as

coronary artery bypass graftinflammationinternal thoracic arteryleft anterior descending arteryoxidative stress

Identifiers

PMID39456434
PMCPMC11505158

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.