Evidence map›Paper›PMID 39456595›Full record

ArticleCancers2024

Ryo Kimura, Yuta Adachi, Kentaro Hirade, Satoru Kisoda, Shogo Yanase, Noriko Shibata, Makoto Ishii, Yutaka Fujiwara, Rui Yamaguchi, Yasuko Fujita and 2 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ryo KimuraDivision of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Yuta AdachiDivision of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.ORCID 0000-0003-1745-5039
Kentaro HiradeDivision of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Satoru KisodaDivision of Cancer Systems Biology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Shogo YanaseDivision of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
Noriko ShibataDepartments of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.
Makoto IshiiDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0003-4396-1664
Yutaka FujiwaraDepartment of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.ORCID 0000-0001-6981-0800
Rui YamaguchiDivision of Cancer Systems Biology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.ORCID 0000-0003-1224-227X
Yasuko FujitaDepartments of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.
Waki HosodaDepartments of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.ORCID 0000-0002-3288-8409
Hiromichi EbiDivision of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.ORCID 0000-0003-3155-7576

Funding

JSPS KAKENHI 22K19473JSPS KAKENHI 24K02313Princess Takamatsu Cancer Research Fund 21-25306
6 · The paper itself

Abstract

BACKGROUND/

objectivesAlthough tyrosine kinase inhibitors (TKIs) targeting EGFR-activating mutations significantly improved the outcome of EGFR-mutant NSCLC, resistance inevitably emerges. Despite the heterogeneity of these resistance mechanisms, many induce activation of MAPK signaling in the presence of EGFR-TKIs. While

methodsWe conducted a single-center retrospective analysis of the presence of

results

conclusions

Indexed as

ARAF amplificationepidermal growth factor receptor tyrosine kinase inhibitorresistancesmall-cell lung cancertransformation

Identifiers

PMID39456595
PMCPMC11506424

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.