Evidence map›Paper›PMID 39456689›Full record

ArticleInternational journal of molecular sciences2024

Molecular Characterization of Sterol C4-Methyl Oxidase in

Yu Ning, Somrita Basu, Fong-Fu Hsu, Mei Feng, Michael Zhuo Wang, Kai Zhang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu NingDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Somrita BasuDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0009-0001-2503-670X
Fong-Fu HsuMass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mei FengDepartment of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0002-8928-8228
Michael Zhuo WangDepartment of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0003-2494-4172
Kai ZhangDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-6616-1806

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
TRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2M
Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
Protein Structure Laboratory P30GM110761 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2014 to 2018
$5.6M
Identification of CYP5122A1 inhibitors as chemical probes for Leishmania biologyR01AI139198 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI WANG, ZHUO MICHAEL · 2019 to 2022
$2.1M
Phospholipid metabolism in LeishmaniaR15AI156746 · NIAID · TEXAS TECH UNIVERSITY · PI ZHANG, KAI · 2021 to 2024
$959k
NIAID NIH HHS R01 AI139198NIAID NIH HHS R15 AI156746NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P60 DK020579NIGMS NIH HHS P20 GM113117NIGMS NIH HHS P30 GM110761NIGMS NIH HHS P41 GM103422NIH HHS 1P20GM113117-19A1NIH HHS 1P30GM110761-19A1NIH HHS 1P41GM103422-20A1NIH HHS 1R01AI139198-18A1NIH HHS 1R15AI156746-21A1NIH HHS P30-DK56341NIH HHS P60-DK20579
6 · The paper itself

Abstract

Sterol biosynthesis requires the oxidative removal of two methyl groups from the C-4 position by sterol C-4-demethylase and one methyl group from the C-14 position by sterol C-14-demethylase. In

Indexed as

Leishmania majorAnimalsCytochrome P-450 Enzyme SystemLeishmaniasis, CutaneousMiceProtozoan ProteinsSterolsCytochrome P-450 Enzyme SystemProtozoan ProteinsSterolsCYP5122A1demethylaseERG25Leishmaniasterol

Identifiers

PMID39456689
PMCPMC11507432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.