Evidence map›Paper›PMID 39456690›Full record

ReviewInternational journal of molecular sciences2024

Obesity Control and Supplementary Nutraceuticals as Cofactors of Brain Plasticity in Multiple Sclerosis Populations.

Lorena Ciumărnean, Oliviu-Florențiu Sârb, Nicu-Cătălin Drăghici, Octavia Sălăgean, Mircea-Vasile Milaciu, Olga-Hilda Orășan, Călin-Vasile Vlad, Irina-Maria Vlad, Teodora Alexescu, Ioana Para and 3 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lorena CiumărneanDepartment of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.
Oliviu-Florențiu SârbDepartment of Clinical Neurosciences, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0003-1115-9650
Nicu-Cătălin DrăghiciDepartment of Clinical Neurosciences, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0009-0000-7811-8277
Octavia SălăgeanDepartment of Nursing, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Mircea-Vasile MilaciuDepartment of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.ORCID 0000-0002-5087-9282
Olga-Hilda OrășanDepartment of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.
Călin-Vasile VladDepartment of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.
Irina-Maria VladDepartment of Clinical Neurosciences, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Teodora AlexescuDepartment of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.ORCID 0000-0003-2756-5784
Ioana ParaDepartment of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.
Simina-Felicia ȚărmureDepartment of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania.ORCID 0000-0002-8041-075X
Elisabeta-Ioana HirișcăuDepartment of Nursing, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Gabriela-Bombonica DogaruDepartment of Medical Rehabilitation, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration within the central nervous system. Brain plasticity, the brain's ability to adapt its structure and function, plays a crucial role in mitigating MS's impact. This paper explores the potential benefits of lifestyle changes and nutraceuticals on brain plasticity in the MS population. Lifestyle modifications, including physical activity and dietary adjustments, can enhance brain plasticity by upregulating neurotrophic factors, promoting synaptogenesis, and reducing oxidative stress. Nutraceuticals, such as vitamin D, omega-3 fatty acids, and antioxidants like alpha lipoic acid, have shown promise in supporting brain health through anti-inflammatory and neuroprotective mechanisms. Regular physical activity has been linked to increased levels of brain-derived neurotrophic factor and improved cognitive function. Dietary interventions, including caloric restriction and the intake of polyphenols, can also positively influence brain plasticity. Integrating these lifestyle changes and nutraceuticals into the management of MS can provide a complementary approach to traditional therapies, potentially improving neurological outcomes and enhancing the quality of life for the MS population.

Indexed as

Dietary SupplementsMultiple SclerosisNeuronal PlasticityObesityAnimalsBrainHumansmultiple sclerosisneurodegenerationneurorehabilitationnutraceuticalsobesity

Identifiers

PMID39456690
PMCPMC11507128

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.