Evidence map›Paper›PMID 39456763›Full record

ArticleInternational journal of molecular sciences2024

Impacts of Hyperglycemia on Epigenetic Modifications in Human Gingival Fibroblasts and Gingiva in Diabetic Rats.

Kento Kojima, Nobuhisa Nakamura, Airi Hayashi, Shun Kondo, Megumi Miyabe, Takeshi Kikuchi, Noritaka Sawada, Tomokazu Saiki, Tomomi Minato, Reina Ozaki and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kento KojimaDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.
Nobuhisa NakamuraDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.ORCID 0000-0003-3265-5194
Airi HayashiDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.
Shun KondoDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.
Megumi MiyabeDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.ORCID 0000-0002-3877-8200
Takeshi KikuchiDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.ORCID 0000-0003-0310-5302
Noritaka SawadaDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.
Tomokazu SaikiDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.
Tomomi MinatoDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.
Reina OzakiDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.
Sachiko SasajimaDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.
Akio MitaniDepartment of Periodontology, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.ORCID 0000-0001-5427-411X
Keiko NaruseDepartment of Internal Medicine, School of Dentistry, Aichi Gakuin University, Suemori-dori, Chikusa-ku, Nagoya 4648651, Japan.ORCID 0000-0002-0062-0694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal disease is considered one of the diabetic complications with high morbidity and severity. Recent studies demonstrated the involvement of the epigenome on diabetic complications. Histone modifications change chromatin architecture and gene activation. Histone modifications have been reported to alter chromatin structure and regulate gene transcription. In this study, we investigated the impacts of H3 lysine 4 trimethylation (H3K4me3) and specific histone methyltransferases of H3K4 methylation, su(var)3-9, enhancer-of-zeste, and trithorax domain 1A (SETD1A) on periodontal tissue affected by the diabetic condition. We observed the increase in H3K4me3 and SETD1A in gingival tissue of diabetic rats compared with the normal rats. Cultured human fibroblasts (hGFs) confirmed a high glucose-induced increase in H3K4me3 and SETD1A. We further demonstrated that high glucose increased the gene expression of

Indexed as

Diabetes Mellitus, ExperimentalEpigenesis, GeneticFibroblastsGingivaHistonesHyperglycemiaAnimalsCells, CulturedHistone-Lysine N-MethyltransferaseHumansMaleMatrix Metalloproteinase 1Matrix Metalloproteinase 13Ratshistone H3 trimethyl Lys4Histone-Lysine N-MethyltransferaseHistonesMatrix Metalloproteinase 1Matrix Metalloproteinase 13epigenomehistone modificationsmatrix metalloproteinasesperiodontal tissue

Identifiers

PMID39456763
PMCPMC11507260

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.