Evidence map›Paper›PMID 39456942›Full record

ArticleInternational journal of molecular sciences2024

Environmental Heat Stress Decreases Sperm Motility by Disrupting the Diurnal Rhythms of Rumen Microbes and Metabolites in Hu Rams.

Qiang-Jun Wang, Huan-Ming Yi, Jing-Yu Ou, Ru Wang, Ming-Ming Wang, Peng-Hui Wang, Xiao-Long He, Wen-Hui Tang, Jia-Hong Chen, Yang Yu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Frontiers in veterinary science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qiang-Jun WangAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0003-2060-1527
Huan-Ming YiAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Jing-Yu OuAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Ru WangAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Ming-Ming WangAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0001-6053-7449
Peng-Hui WangAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Xiao-Long HeAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Wen-Hui TangAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Jia-Hong ChenAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Yang YuQinghai Provincial Key Laboratory of Adaptive Management on Alpine Grassland, Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China.
Chun-Ping ZhangQinghai Provincial Key Laboratory of Adaptive Management on Alpine Grassland, Qinghai Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China.
Chun-Huan RenAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Zi-Jun ZhangAnhui Provincial Key Laboratory of Conservation and Germplasm Innovation of Local Livestock, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-4292-4709

Funding

National Key Research and Development Program of China 2022YFD1300202National Natural Science Foundation of China 32302802the earmarked fund for CARS CARS-38
6 · The paper itself

Abstract

Heat stress (HS) has become a common stressor, owing to the increasing frequency of extreme high-temperature weather triggered by global warming, which has seriously affected the reproductive capacity of important livestock such as sheep. However, little is known about whether HS reduces sperm motility by inducing circadian rhythm disorders in rumen microorganisms and metabolites in sheep. In this study, the year-round reproduction of two-year-old Hu rams was selected, and the samples were collected in May and July 2022 at average environmental temperatures between 18.71 °C and 33.58 °C, respectively. The experiment revealed that the mean temperature-humidity index was 86.34 in July, indicating that Hu rams suffered from HS. Our research revealed that HS significantly decreased sperm motility in Hu rams. Microbiome analysis further revealed that HS reshaped the composition and circadian rhythm of rumen microorganisms, leading to the circadian disruption of microorganisms that drive cortisol and testosterone synthesis. Serum indicators further confirmed that HS significantly increased the concentrations of cortisol during the daytime and decreased the testosterone concentration at the highest body temperature. Untargeted metabolomics analysis revealed that the circadian rhythm of rumen fluid metabolites in the HS group was enriched by the cortisol and steroid synthesis pathways. Moreover, HS downregulated metabolites, such as kaempferol and L-tryptophan in rumen fluid and seminal plasma, which are associated with promotion of spermatogenesis and sperm motility; furthermore, these metabolites were found to be strongly positively correlated with

Indexed as

Circadian RhythmRumenSperm MotilityAnimalsGastrointestinal MicrobiomeHeat-Shock ResponseHydrocortisoneMaleSheepHydrocortisonecircadian rhythmmetabolomerumen microorganismsperm motility

Identifiers

PMID39456942
PMCPMC11508439

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.