Evidence map›Paper›PMID 39457017›Full record

ReviewInternational journal of molecular sciences2024

Emerging Nanomedicine Approaches in Targeted Lung Cancer Treatment.

Isaic Alexandru, Lavinia Davidescu, Alexandru Cătălin Motofelea, Tudor Ciocarlie, Nadica Motofelea, Dan Costachescu, Monica Steluta Marc, Noemi Suppini, Alina Simona Șovrea, Răzvan-Lucian Coșeriu and 3 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Smart nanoplatforms for early detection and immune modulation in lung cancer.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Isaic AlexandruDepartment X of General Surgery, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Lavinia DavidescuDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.ORCID 0000-0003-4343-4397
Alexandru Cătălin MotofeleaDepartment of Internal Medicine, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Tudor CiocarlieDepartment VII Internal Medicine II, Discipline of Cardiology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Nadica MotofeleaDepartment of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania.ORCID 0009-0007-7597-823X
Dan CostachescuRadiology Department, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.ORCID 0000-0002-5944-3522
Monica Steluta MarcDiscipline of Pulmonology, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.ORCID 0000-0003-1160-9164
Noemi SuppiniDiscipline of Pulmonology, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.ORCID 0000-0003-0695-6372
Alina Simona ȘovreaDepartment of Morphological Sciences, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
Răzvan-Lucian CoșeriuDepartment of Microbiology, University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540142 Târgu-Mures, Romania.ORCID 0000-0001-9627-4513
Daniela-Andreea BondorDepartment of Medical Biochemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Laura-Gabriela BobeicăDepartment of Medical Biochemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Andreea CrinteaDepartment of Medical Biochemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer, the leading cause of cancer-related deaths worldwide, is characterized by its aggressive nature and poor prognosis. As traditional chemotherapy has the disadvantage of non-specificity, nanomedicine offers innovative approaches for targeted therapy, particularly through the development of nanoparticles that can deliver therapeutic agents directly to cancer cells, minimizing systemic toxicity and enhancing treatment efficacy. VEGF and VEGFR are shown to be responsible for activating different signaling cascades, which will ultimately enhance tumor development, angiogenesis, and metastasis. By inhibiting VEGF and VEGFR signaling pathways, these nanotherapeutics can effectively disrupt tumor angiogenesis and proliferation. This review highlights recent advancements in nanoparticle design, including lipid-based, polymeric, and inorganic nanoparticles, and their clinical implications in improving lung cancer outcomes, exploring the role of nanomedicine in lung cancer diagnoses and treatment.

Indexed as

Lung NeoplasmsNanomedicineNanoparticlesAnimalsAntineoplastic AgentsDrug Delivery SystemsHumansMolecular Targeted TherapyNeovascularization, PathologicSignal TransductionVascular Endothelial Growth Factor AAntineoplastic AgentsVascular Endothelial Growth Factor Alung cancernanomedicinenanoparticlesVEGFVEGFR

Identifiers

PMID39457017
PMCPMC11508987

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.