Evidence map›Paper›PMID 39457127›Full record

ArticleChildren (Basel, Switzerland)2024

An Epidemiological Perspective on New Pediatric Cases of Type 1 Diabetes and Vitamin D Deficiency in South-East Romania: A Retrospective Study.

Maria Ursu, Mariana Cretu-Stuparu, Gabriela Gurau, Luciana-Carmen Nitoi, Aurel Nechita, Manuela Arbune

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Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Maria UrsuSchool for Doctoral Studies in Biomedical Sciences, "Dunarea de Jos" University, 800008 Galati, Romania.ORCID 0000-0002-1966-5737
Mariana Cretu-Stuparu"St. Ioan" Clinic Emergency Children Hospital, 800487 Galati, Romania.ORCID 0000-0002-0626-2023
Gabriela Gurau"St. Ioan" Clinic Emergency Children Hospital, 800487 Galati, Romania.
Luciana-Carmen NitoiMedical Clinical Department, "Dunarea de Jos" University, 800008 Galati, Romania.
Aurel Nechita"St. Ioan" Clinic Emergency Children Hospital, 800487 Galati, Romania.
Manuela ArbuneMedical Clinical Department, "Dunarea de Jos" University, 800008 Galati, Romania.ORCID 0000-0002-4762-0755

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study is to analyze the epidemiological characteristics and the biological profile of children from the southeast of Romania who have been newly diagnosed with type 1 diabetes (T1DM) and to investigate the potential relationships between vitamin D deficiency and the onset of this disease, especially in the context of the COVID-19 pandemic.

methodsThis is a retrospective study that included 79 children under the age of 18 who were diagnosed with T1DM at the St. Ioan Galati Children's Emergency Clinical Hospital between 2018 and 2023. Their demographic data (age, sex, and home environment), medical history (family medical history, birth weight, Apgar score, and type of nutrition), and biological parameters, including glycemia, HbA1C, and vitamin D level, were collected. We used advanced statistical methods to compare the levels of vitamin D in the children with T1DM with a control group of nondiabetic children.

resultsThe demographic characteristics of new T1DM are a median age of 9 and female/male sex ratio of 1:3, with 50.6% living in urban areas, 59.5% with a normal body mass index, and 74.6% presenting with ketoacidosis. Vitamin D deficiency was found in 52% of diabetic cases compared to 2.53% in the nondiabetic controls.

conclusionsThere is an increasing incidence of pediatric T1DM. Diabetic ketoacidosis was frequently diagnosed as an initial manifestation and has frequently accompanied lower levels of vitamin D. Children with T1DM showed significant vitamin D deficiencies compared to the control group, highlighting the need for the monitoring and supplementation of this vitamin.

Indexed as

metabolic disorderpediatric endocrinologytype 1 diabetesvitamin D

Identifiers

PMID39457127
PMCPMC11506627

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.