Evidence mapPaperPMID 39457565Full record

ReviewBiomedicines2024

Dyslipidemia in Pregnancy: A Systematic Review of Molecular Alterations and Clinical Implications.

Agnesa Preda, Silviu-Daniel Preda, Maria Mota, Dominic Gabriel Iliescu, Lucian George Zorila, Alexandru Cristian Comanescu, Adina Mitrea, Diana Clenciu, Eugen Mota, Ionela Mihaela Vladu

Abstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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  10. Metabolic Roles of Fatty Acid Binding Protein 4 (FABP4) in Fetal and Maternal Health and Maintenance of Pregnancy in Women with Obesity: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Agnesa PredaDepartment of Obstetrics and Gynecology, Clinical County Emergency Hospital Craiova, 200642 Craiova, Romania.
Silviu-Daniel PredaDepartment of Surgery, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0002-0232-0070
Maria MotaDoctoral School, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Dominic Gabriel IliescuDepartment of Obstetrics and Gynecology, Clinical County Emergency Hospital Craiova, 200642 Craiova, Romania.ORCID 0000-0002-7823-3387
Lucian George ZorilaDepartment of Obstetrics and Gynecology, Clinical County Emergency Hospital Craiova, 200642 Craiova, Romania.ORCID 0000-0002-2358-7866
Alexandru Cristian ComanescuDepartment of Obstetrics and Gynecology, Clinical County Emergency Hospital Craiova, 200642 Craiova, Romania.
Adina MitreaDepartment of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0002-5310-3033
Diana ClenciuDepartment of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Eugen MotaDoctoral School, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Ionela Mihaela VladuDepartment of Diabetes, Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDyslipidemia in pregnancy presents unique clinical challenges due to its effects on maternal and fetal health. This systematic review hypothesizes that molecular alterations in lipid metabolism during pregnancy contribute to adverse pregnancy outcomes and seeks to identify the clinical implications of these changes. The rationale behind this review stems from the increased risk of complications such as preeclampsia, intrauterine growth restriction, and acute pancreatitis associated with dyslipidemia in pregnancy. The primary objective is to examine the interplay between lipid metabolism and pregnancy outcomes.

methodsTo achieve this, a systematic review following PRISMA guidelines was conducted, with a comprehensive search of the PubMed database covering articles from January 2014 to June 2024. Inclusion criteria focused on studies assessing molecular alterations and clinical outcomes of dyslipidemia in pregnancy, while case reports and relevant clinical trials were analyzed to evaluate both maternal and fetal outcomes. A total of 12 studies were included in the final analysis.

resultsThis study provided evidence of the need for early detection and management strategies to reduce risks. The outcomes revealed significant associations between dyslipidemia and adverse maternal outcomes such as preeclampsia, gestational diabetes, and pancreatitis, as well as fetal outcomes like preterm birth and fetal distress.

conclusionsEarly lipid monitoring and intervention are crucial in mitigating these risks and suggests that a multidisciplinary approach is necessary to improve maternal and fetal health in pregnancies complicated by dyslipidemia.

Indexed as

dyslipidemiafetal outcomesmaternal outcomesmolecular

Identifiers

PMID39457565
PMCPMC11504282

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.