Evidence map›Paper›PMID 39457748›Full record

ArticleBehavioral sciences (Basel, Switzerland)2024

Examining the Role of Neuroticism Polygenic Risk in Late Life Cognitive Change: A UK Biobank Study.

Niki Akbarian, Mahbod Ebrahimi, Fernanda C Dos Santos, Sara Sadat Afjeh, Mohamed Abdelhack, Marcos Sanches, Andreea O Diaconescu, Tarek K Rajji, Daniel Felsky, Clement C Zai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioral sciences (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Niki AkbarianTanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.ORCID 0009-0008-4552-5958
Mahbod EbrahimiTanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
Fernanda C Dos SantosTanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.ORCID 0000-0002-4590-5722
Sara Sadat AfjehTanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.ORCID 0000-0002-6352-9310
Mohamed AbdelhackKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.ORCID 0000-0002-6753-3237
Marcos SanchesBiostatistics Core, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.ORCID 0000-0001-9075-1761
Andreea O DiaconescuInstitute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-3633-9757
Tarek K RajjiInstitute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
Daniel FelskyInstitute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
Clement C ZaiTanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
James L KennedyTanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.

Funding

Institute of Medical Science - University of Toronto Open FellowshipOntario Graduate Scholarship N/ATanenbaum Centre for Pharmacogenetics at the Centre for Addiction and Mental Health N/A
6 · The paper itself

Abstract

Cognitive decline is a public health concern affecting about 50 million individuals worldwide. Neuroticism, defined as the trait disposition to experience intense and frequent negative emotions, has been associated with an increased risk of late-life cognitive decline. However, the underlying biological mechanisms of this association remain unknown. This study investigated the relationship between genetic predisposition to neuroticism, computed by polygenic risk score (PRS), and performance in cognitive domains of reasoning, processing speed, visual attention, and memory in individuals over age 60. The sample consisted of UK Biobank participants with genetic and cognitive data available (N = 10,737, 4686 females; mean age = 63.4 ± 2.71). The cognitive domains were assessed at baseline for all participants and seven years later for a subset (N = 645, 262 females; mean age = 62.9 ± 2.44). Neuroticism PRS was not associated cross-sectionally with cognitive measures (

Indexed as

cognitioncognitive declineneuroticismpersonality traitspolygenic risk

Identifiers

PMID39457748
PMCPMC11504883

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.