Evidence map›Paper›PMID 39457946›Full record

ArticleAnimals : an open access journal from MDPI2024

Nitidine Chloride Alleviates Hypoxic Stress via PINK1-Parkin-Mediated Mitophagy in the Mammary Epithelial Cells of Milk Buffalo.

Zhiwei Kong, Haichang Pan, Zi Wang, Alida Abla, Yingming Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhiwei KongGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Department of Animal Sciences, Guangxi University, Nanning 530004, China.ORCID 0000-0003-0404-6498
Haichang PanGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Department of Animal Sciences, Guangxi University, Nanning 530004, China.
Zi WangGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Department of Animal Sciences, Guangxi University, Nanning 530004, China.
Alida AblaGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Department of Animal Sciences, Guangxi University, Nanning 530004, China.
Yingming WeiInstitute for Agricultural and Animal Husbandry Industry Development, Guangxi University, Nanning 530004, China.

Funding

Guangxi University High level Talent Introduction Project A3340051019National Natural Science Foundation of China 32102576The Guangxi Science and Technology Program AD23026165
6 · The paper itself

Abstract

Hypoxia in the mammary gland epithelial cells of milk buffalo (BMECs) can affect milk yield and composition, and it can even cause metabolic diseases. Nitidine chloride (NC) is a natural alkaloid with antioxidant properties that can scavenge excessive reactive oxygen species (ROS). However, the effect of NC on the hypoxic injury of BMECs and its molecular mechanisms are still unknown. Here, an immunofluorescence assay, transmission electron microscopy (TEM), and flow cytometry, combined with untargeted metabolomics, were used to investigate the protective effect of NC on hypoxic stress injury in BMECs. It was found that NC can significantly reduce cell activity (

Indexed as

hypoxic stressmilk buffalo mammary epithelial cellsmitophagynitidine chloridePINK1-Parkin pathway

Identifiers

PMID39457946
PMCPMC11505235

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.