Evidence mapPaperPMID 39458427Full record

ReviewNutrients2024

The Potential Effects of Red Wine and Its Components on Neurocognitive Disorders: A Narrative Review.

Virginia Boccardi, Luca Tagliafico, Angelica Persia, Elena Page, Silvia Ottaviani, Anna Laura Cremonini, Consuelo Borgarelli, Livia Pisciotta, Patrizia Mecocci, Alessio Nencioni and 1 more

Abstract readReview
In one paragraph

Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Virginia BoccardiDivision of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0003-2134-1122
Luca TagliaficoDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-2372-9999
Angelica PersiaDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.
Elena PageDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0009-0006-6162-3457
Silvia OttavianiDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-8278-793X
Anna Laura CremoniniIRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Consuelo BorgarelliIRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0001-8210-5604
Livia PisciottaDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0001-7080-9807
Patrizia MecocciDivision of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0003-0729-5246
Alessio NencioniDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.
Fiammetta MonacelliDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aging population is associated with a net increase in the incidence and prevalence of chronic-degenerative diseases, particularly neurocognitive disorders. Therefore, the identification of preventative strategies to restrain the burden of such chronic conditions is of key relevance. Red wine and its components have accumulated evidence regarding their positive effects in terms of neurological pathologies associated with neurocognitive symptoms.

methodsBased on this background, the present narrative review aims to summarize the state-of-the-art evidence on the effects of red wine and its components on neurocognitive disorders in both preclinical and clinical settings.

resultsThe main findings highlight a protective effect of wine polyphenols present in red wine on dementia in different preclinical models of cognitive decline. The current translational clinical evidence remains uncertain, especially considering the risk-to-benefit ratio of alcohol consumption on brain health.

conclusionsGiven the overall health risks associated with red wine consumption and consistent with the prevailing guidelines in the literature, there is insufficient evidence to support light-to-moderate red wine consumption as an effective strategy for preventing these diseases. However, the largely preclinical findings on polyphenols derived from red wine remain of significant interest in this context.

Indexed as

Neurocognitive DisordersPolyphenolsWineAlcohol DrinkingAnimalsBrainCognitive DysfunctionHumansPolyphenolsclinical studiesdementianeurocognitive disordersneurodegenerative diseasespolyphenolspreclinical studiespreventionred wineresveratrol

Identifiers

PMID39458427
PMCPMC11510231

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.