Evidence map›Paper›PMID 39458497›Full record

ArticleNutrients2024

From Mother to Child: Epigenetic Signatures of Hyperglycemia and Obesity during Pregnancy.

Marica Franzago, Paola Borrelli, Marta Di Nicola, Pierluigi Cavallo, Ebe D'Adamo, Luciano Di Tizio, Diego Gazzolo, Liborio Stuppia, Ester Vitacolonna

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Transient fetal hyperglycemia reprograms adipogenesis, lipogenesis, and insulin signaling in zebrafish.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marica FranzagoDepartment of Medicine and Aging, School of Medicine, and Health Sciences, "G. D'Annunzio" University, Via dei Vestini, Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-4830-8034
Paola BorrelliLaboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, "G. D'Annunzio" University, Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-9389-627X
Marta Di NicolaLaboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, "G. D'Annunzio" University, Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1748-1931
Pierluigi CavalloDepartment of Medicine and Aging, School of Medicine, and Health Sciences, "G. D'Annunzio" University, Via dei Vestini, Chieti-Pescara, 66100 Chieti, Italy.
Ebe D'AdamoNeonatal Intensive Care Unit, "G. D'Annunzio" University, 66100 Chieti, Italy.
Luciano Di TizioDepartment of Obstetrics and Gynaecology, SS. Annunziata Hospital, "G. D'Annunzio" University, 66100 Chieti, Italy.
Diego GazzoloDepartment of Medicine and Aging, School of Medicine, and Health Sciences, "G. D'Annunzio" University, Via dei Vestini, Chieti-Pescara, 66100 Chieti, Italy.
Liborio StuppiaCenter for Advanced Studies and Technology (CAST), "G. D'Annunzio" University, Chieti-Pescara, 66100 Chieti, Italy.
Ester VitacolonnaDepartment of Medicine and Aging, School of Medicine, and Health Sciences, "G. D'Annunzio" University, Via dei Vestini, Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1756-661X

Funding

Italian Ministry of Health D73C22001670006
6 · The paper itself

Abstract

backgroundIn utero exposure to maternal hyperglycemia and obesity can trigger detrimental effects in the newborn through epigenetic programming. We aimed to assess the DNA methylation levels in the promoters of

methodsA total of 101 Caucasian mother-infant pairs were included in this study. Sociodemographic characteristics, clinical parameters, physical activity, and adherence to the Mediterranean diet were evaluated in the third trimester of pregnancy. Clinical parameters of the newborns were recorded at birth.

resultsA negative relationship between

conclusionsThese results support the role of maternal

Indexed as

Diabetes, GestationalDNA MethylationEpigenesis, GeneticHyperglycemiaObesityPlacentaReceptor, Melanocortin, Type 4AdultBirth WeightFemaleHumansInfant, NewbornLipoprotein LipaseMalePregnancyPrenatal Exposure Delayed EffectsLipoprotein LipaseMC4R protein, humanReceptor, Melanocortin, Type 4DNA methylationepigenetic modificationsfetal programminggene expressiongestational diabetesLPLMC4Robesity

Identifiers

PMID39458497
PMCPMC11510513

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.