Evidence map›Paper›PMID 39458548›Full record

ArticleNutrients2024

Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI.

Martin S Lietzén, Maria Angela Guzzardi, Ronja Ojala, Jaakko Hentilä, Marja A Heiskanen, Sanna M Honkala, Riikka Lautamäki, Eliisa Löyttyniemi, Anna K Kirjavainen, Johan Rajander and 6 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Martin S LietzénTurku PET Centre, University of Turku, 20521 Turku, Finland.
Maria Angela GuzzardiInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Ronja OjalaTurku PET Centre, University of Turku, 20521 Turku, Finland.ORCID 0000-0002-2393-0281
Jaakko HentiläTurku PET Centre, University of Turku, 20521 Turku, Finland.
Marja A HeiskanenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20521 Turku, Finland.ORCID 0000-0002-3817-0043
Sanna M HonkalaTurku PET Centre, University of Turku, 20521 Turku, Finland.
Riikka LautamäkiHeart Centre, Turku University Hospital, 20521 Turku, Finland.
Eliisa LöyttyniemiDepartment of Biostatistics, University of Turku, 20520 Turku, Finland.
Anna K KirjavainenTurku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, 20521 Turku, Finland.
Johan RajanderTurku PET Centre, Accelerator Laboratory, Åbo Akademi University, 20500 Turku, Finland.ORCID 0000-0003-3591-0963
Tarja MalmA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Leo LahtiDepartment of Computing, University of Turku, 20521 Turku, Finland.ORCID 0000-0001-5537-637X
Juha O RinneTurku PET Centre, University of Turku, 20521 Turku, Finland.
Kirsi H PietiläinenObesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-8522-1288
Patricia IozzoInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Jarna C HannukainenTurku PET Centre, University of Turku, 20521 Turku, Finland.ORCID 0000-0002-8692-4049

Funding

Emil Aaltonen foundationMaija and Matti Vaskio Foundationthe Finnish Cultural Foundationthe Finnish Diabetes Research Foundation
6 · The paper itself

Abstract

BACKGROUND/

objectivesObesity impairs intestinal glucose uptake (GU) (intestinal uptake of circulating glucose from blood) and alters gut microbiome. Exercise improves intestinal insulin-stimulated GU and alters microbiome. Genetics influence the risk of obesity and gut microbiome. However, the role of genetics on the effects of exercise on intestinal GU and microbiome is unclear.

methodsTwelve monozygotic twin pairs discordant for BMI (age 40.4 ± 4.5 years, BMI heavier 36.7 ± 6.0, leaner 29.1 ± 5.7, 8 female pairs) performed a six-month-long training intervention. Small intestine and colonic insulin-stimulated GU was studied using [

resultsTen pairs completed the intervention. At baseline, heavier twins had lower small intestine and colonic GU (

conclusionsObesity impairs insulin-stimulated intestinal GU independent of genetics. Though both twin groups exhibited some microbiota changes, most changes in insulin-stimulated colon GU and microbiota were significant in the leaner twins.

Indexed as

Body Mass IndexExerciseGastrointestinal MicrobiomeTwins, MonozygoticAdultBlood GlucoseFecesFemaleGlucoseHumansInsulinIntestine, SmallMaleMiddle AgedObesityBlood GlucoseGlucoseInsulingut microbiotainsulin sensitivityintestinephysical exercise

Identifiers

PMID39458548
PMCPMC11510543

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.