Modification of 316L Stainless Steel, Nickel Titanium, and Cobalt Chromium Surfaces by Irreversible Immobilization of Fibronectin: Towards Improving the Coronary Stent Biocompatibility.

Hesam Dadafarin, Evgeny Konkov, Hojatollah Vali, Irshad Ali, Sasha Omanovic

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hesam DadafarinDepartment of Chemical Engineering, McGill University, 3610 University St., Montreal, QC H3A 0C5, Canada.

Evgeny KonkovDepartment of Chemical Engineering, McGill University, 3610 University St., Montreal, QC H3A 0C5, Canada.

Hojatollah ValiDepartment of Anatomy and Cell Biology, McGill University, 3640 University St., Montreal, QC H3A 0C7, Canada.

Irshad AliDepartment of Chemical Engineering, Faculty of Mechanical, Chemical and Industrial Engineering, University of Engineering & Technology, Jamrud Road, Peshawar 25000, Pakistan.

Sasha OmanovicDepartment of Chemical Engineering, McGill University, 3610 University St., Montreal, QC H3A 0C5, Canada.ORCID 0000-0001-9932-4272

Funding

Collaborative Health Research Program grant NSERC CHRP J 350990-08

6 · The paper itself

Abstract

An extracellular matrix protein, fibronectin (Fn), was covalently immobilized on 316L stainless steel, L605 cobalt chromium (CoCr), and nickel titanium (NiTi) surfaces through an 11-mercaptoundecanoic acid (MUA) self-assembled monolayer (SAM) pre-formed on these surfaces. Polarization modulation infrared reflection adsorption spectroscopy (PM-IRRAS) confirmed the presence of Fn on the surfaces. The Fn monolayer attached to the SAM was found to be stable under fluid shear stress. Deconvolution of the Fn amide I band indicated that the secondary structure of Fn changes significantly upon immobilization to the SAM-functionalized metal substrate. Scanning electron microscopy and energy dispersive X-ray analysis revealed that the spacing between Fn molecules on a modified commercial stent surface is approximately 66 nm, which has been reported to be the most appropriate spacing for cell/surface interactions.

Indexed as

FibronectinsNickelStainless SteelStentsSurface PropertiesTitaniumAdsorptionBiocompatible MaterialsChromiumCobaltFatty AcidsHumansImmobilized ProteinsSulfhydryl Compounds11-mercaptoundecanoic acidBiocompatible MaterialsChromiumCobaltFatty AcidsFibronectinsImmobilized ProteinsNickelStainless SteelSulfhydryl CompoundsTitaniumtitanium nickelidebiomaterialselectrochemical techniquesinfrared spectroscopy (IR)monolayerssurface properties

Identifiers

PMID39459295

DOI10.3390/molecules29204927

PMCPMC11510294

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.