Evidence map›Paper›PMID 39459469›Full record

ArticleMedicina (Kaunas, Lithuania)2024

Targeting the Sirtuin-1/PPAR-Gamma Axis, RAGE/HMGB1/NF-κB Signaling, and the Mitochondrial Functions by Canagliflozin Augments the Protective Effects of Levodopa/Carbidopa in Rotenone-Induced Parkinson's Disease.

Mennatallah A Elkady, Ahmed M Kabel, Lamees M Dawood, Azza I Helal, Hany M Borg, Hanan Abdelmawgoud Atia, Nesreen M Sabry, Nouran M Moustafa, El-Shaimaa A Arafa, Shuruq E Alsufyani and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mennatallah A ElkadyPharmacology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Ahmed M KabelPharmacology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.ORCID 0000-0002-5101-8011
Lamees M DawoodMedical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31511, Egypt.
Azza I HelalDepartment of Histology and Cell Biology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.
Hany M BorgPhysiology Department, Faculty of Medicine, Kafrelsheikh University, Kafr El-Shaikh 33516, Egypt.
Hanan Abdelmawgoud AtiaDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 2440, Saudi Arabia.
Nesreen M SabryClinical Oncology Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Nouran M MoustafaMedical Microbiology & Immunology Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
El-Shaimaa A ArafaCollege of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates.ORCID 0000-0002-9034-6624
Shuruq E AlsufyaniDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0002-5567-6169
Hany H ArabDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Funding

Taif University TU-DSPP-2024-116
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CanagliflozinCarbidopaDisease Models, AnimalHMGB1 ProteinLevodopaMice, Inbred BALB CNF-kappa BPPAR gammaRotenoneSignal TransductionSirtuin 1AnimalsDrug CombinationsMaleMiceMitochondriaCanagliflozinCarbidopacarbidopa, levodopa drug combinationDrug CombinationsHMGB1 ProteinLevodopaNF-kappa BPPAR gammaReceptor for Advanced Glycation End ProductsRotenoneSirtuin 1canagliflozinlevodopa/carbidopamiceParkinson’s diseasepathophysiologysirtuin-1/PPAR-gamma axis

Identifiers

PMID39459469
PMCPMC11509249

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.