Hypoxia Modulates Sodium Chloride Co-transporter via CaMKII-β Pathway: An In Vitro Study with mDCT15 Cells.

Lijuan Liang, Kohei Ueda, Sayoko Ogura, Tatsuo Shimosawa

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Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Lijuan LiangDepartment of Clinical Laboratory, International University of Health and Welfare, Chiba 286-8686, Japan.

Kohei UedaDepartment of Physiology, International University of Health and Welfare, Chiba 286-8686, Japan.ORCID 0000-0002-9411-1611

Sayoko OguraDepartment of Pathology and Microbiology, Division of Laboratory Medicine, Nihon University School of Medicine, Tokyo 173-8610, Japan.

Tatsuo ShimosawaDepartment of Clinical Laboratory, International University of Health and Welfare, Chiba 286-8686, Japan.ORCID 0000-0002-8742-5129

Funding

JSPS Kakenhi 21K08234JSPS Kakenhi 23K06336

6 · The paper itself

Abstract

backgroundHypoxia plays a crucial role in regulating various cellular functions, including ion-transport mechanisms in the kidney. The sodium-chloride co-transporter (NCC) is essential for sodium reabsorption in the distal convoluted tubule (DCT). However, the effects of hypoxia on NCC expression and its regulatory pathways remain unclear. We aimed to explore the effects and potential mechanisms of hypoxia on NCC in vitro.

methodsmDCT15 cells were treated with cobalt chloride (CoCl

resultsA time-dependent upregulation of NCC and CaMKII-β expression in response to CoCl

conclusionsHypoxia, mediated through cobalt chloride treatment, upregulates NCC expression via the CaMKII-β pathway in mDCT15 cells.

Indexed as

CaMKII-βcobalt chloridehypoxiasodium-chloride co-transporter

Identifiers

PMID39459529

DOI10.3390/life14101229

PMCPMC11508333

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.