Evidence map›Paper›PMID 39461367›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2024

Targeted NAD

Li Yin, Yao Tong, Ruosen Xie, Zhanpeng Zhang, Zain Husain Islam, Kaijie Zhang, Jacobus Burger, Nicholas Hoyt, Eric William Kent, William Aaron Marcum and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Li YinDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60603, USA; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Department of Vascular Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang 310058, China.
Yao TongWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53715, USA.
Ruosen XieWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53715, USA.
Zhanpeng ZhangWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53715, USA.
Zain Husain IslamDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Kaijie ZhangDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60603, USA; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA; Department of Vascular Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang 310058, China.
Jacobus BurgerWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA.
Nicholas HoytDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Eric William KentDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
William Aaron MarcumDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Campbell JohnstonDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Rohan KanchettyDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Zoe TetzDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Sophia StanisicDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Yitao HuangDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Lian-Wang GuoDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Shaoqin GongWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI 53715, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53715, USA. Electronic address: shaoqingong@wisc.edu.
Bowen WangDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60603, USA; Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: bowenwang@northwestern.edu.

Funding

Targeting PERK: An Endothelium-Protective Stent-Free Strategy for Mitigation of Intimal Hyperplasia After Vascular SurgeryR01HL143469 · NHLBI · UNIVERSITY OF VIRGINIA · PI GONG, SHAOQIN -, GUO, LIANWANG · 2018 to 2021
$2.4M
Development of unimolecular nanoparticle-mediated periadventitial drug delivery system for sustained and targeted inhibition of intimal hyperplasia following open vascular reconstructionR01HL129785 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GONG, SHAOQIN -, GUO, LIANWANG · 2016 to 2019
$2.0M
Development of NAD+ loaded nanoparticles as a safe and efficient strategy to combat sepsis.R21AI165977 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GONG, SHAOQIN - · 2022 to 2023
$424k
NHLBI NIH HHS R01 HL129785NHLBI NIH HHS R01 HL143469NIAID NIH HHS R21 AI165977
6 · The paper itself

Abstract

Endovascular interventions often fail due to restenosis, primarily caused by smooth muscle cell (SMC) proliferation, leading to intimal hyperplasia (IH). Current strategies to prevent restenosis are far from perfect and impose significant collateral damage on the fragile endothelial cell (EC), causing profound thrombotic risks. Nicotinamide adenine dinucleotide (NAD

Indexed as

HyperplasiaNADNanoparticlesAnimalsBiomimetic MaterialsBiomimeticsCell ProliferationCells, CulturedEndothelial CellsEndothelium, VascularHumansMaleProof of Concept StudyRatsRats, Sprague-DawleyTunica IntimaNADIntimal hyperplasiaNAD+ repletionNanotherapyRe-endothelialization

Identifiers

PMID39461367
PMCPMC11611612

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.