Evidence map›Paper›PMID 39462310›Full record

ArticleJournal of the American Society of Nephrology : JASN2025

The Selective Endothelin Receptor Antagonist SC0062 in IgA Nephropathy: A Randomized Double-Blind Placebo-Controlled Clinical Trial.

Hiddo J L Heerspink, Xiaoying Du, Yan Xu, Yanning Zhang, Bin Liu, Guangyu Bi, Chengyun Xu, Qun Luo, Henglan Wu, Jianxin Wan and 13 more

Abstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. IgA nephropathy management: what does the future hold?Kidney international supplements · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Unlocking the Potential of SC0062: A New Horizon in IgA Nephropathy Treatment?Journal of the American Society of Nephrology : JASN · 2025
    Article
  14. From Despair to Promise: The Dawn of Novel Treatment in IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hiddo J L HeerspinkDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-3126-3730
Xiaoying DuKidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.ORCID 0009-0004-5891-0215
Yan XuDepartment of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Yanning ZhangDepartment of Nephrology, General Hospital of Northern Theater Command, Shenyang, China.
Bin LiuDepartment of Nephrology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.ORCID 0009-0007-7565-5844
Guangyu BiDepartment of Nephrology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Chengyun XuDepartment of Nephrology, Nanchang University Second Affiliated Hospital, Nanchang, China.
Qun LuoDepartment of Nephrology, Ningbo No. 2 Hospital, Ningbo, China.
Henglan WuDepartment of Nephrology, First Hospital of Jiaxing, Jiaxing, China.
Jianxin WanDepartment of Nephrology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0002-6733-0472
Liou CaoDepartment of Nephrology, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China.
Rong WangDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.ORCID 0009-0006-8675-2837
Qiuling FanDepartment of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hong ChengDepartment of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-7908-3333
Lixia XuDepartment of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Jiyi HuangDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Aimin ZhongDepartment of Nephrology, Jiangxi Provincial People's Hospital, Nanchang, China.
Qingfeng PengDepartment of Nephrology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, China.
Yongjiang HeiResearch and Development Division, Biocity Biopharmaceutics Co., Ltd., Wuxi, China.ORCID 0009-0006-5847-5318
Yiwei WangResearch and Development Division, Biocity Biopharmaceutics Co., Ltd., Wuxi, China.ORCID 0009-0005-4148-355
Bo ZhouResearch and Development Division, Biocity Biopharmaceutics Co., Ltd., Wuxi, China.ORCID 0009-0000-0980-9517
Liqin ZhangResearch and Development Division, Biocity Biopharmaceutics Co., Ltd., Wuxi, China.ORCID 0009-0002-4498-4868
Jianghua ChenKidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.ORCID 0000-0002-3282-3998

Funding

Biocity Biopharmaceuticals
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39462310
PMCPMC11975243

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.