Evidence map›Paper›PMID 39462312›Full record

ArticleBMC microbiology2024

Does gut microbiota dysbiosis impact the metabolic alterations of hydrogen sulfide and lanthionine in patients with chronic kidney disease?

Yuselys Garcia-Martinez, Elena Alexandrova, Valerio Iebba, Carlo Ferravante, Michelle Spinelli, Gianluigi Franci, Angela Amoresano, Alessandro Weisz, Francesco Trepiccione, Margherita Borriello and 2 more

Abstract read
In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Supplementation withThe veterinary quarterly · 2026
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  2. Higher abundance ofmSystems · 2026
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  3. Review
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  7. Article
  8. Potential and Challenges ofFoods (Basel, Switzerland) · 2025
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuselys Garcia-MartinezDepartment of Translational Medical Science, University of Campania Luigi Vanvitelli, Naples, Italy. yuselys.garciamartinez@unicampania.it.
Elena AlexandrovaDepartment of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.
Valerio IebbaGustave Roussy Cancer Campus, ClinicObiome, Villejuif, Paris, France.
Carlo FerravanteDepartment of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.
Michelle SpinelliDepartment of Translational Medical Science, University of Campania Luigi Vanvitelli, Naples, Italy.
Gianluigi FranciDepartment of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.
Angela AmoresanoDepartment of Chemical Sciences, University of Napoli Federico II, Naples, Italy.
Alessandro WeiszDepartment of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Italy.
Francesco TrepiccioneDepartment of Translational Medical Science, University of Campania Luigi Vanvitelli, Naples, Italy.
Margherita BorrielloDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Diego IngrossoDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Alessandra F PernaDepartment of Translational Medical Science, University of Campania Luigi Vanvitelli, Naples, Italy.

Funding

European Union's Horizon 2020 research and innovation program Grant agreement No [860329]
6 · The paper itself

Abstract

backgroundChronic Kidney Disease (CKD) is characterized by a methionine-related metabolic disorder involving reduced plasma levels of hydrogen sulfide (H

methodsThe gut microbiota of 88 CKD patients (non-dialysis, hemodialysis, and transplant patients) and 26 healthy controls were profiled using 16 S-amplicon sequencing. H

resultsThe CKD population exhibited a tenfold increase in serum lanthionine associated with kidney dysfunction. Despite lanthionine retention, hemodialysis and transplant patients had significantly lower serum H

conclusionsThe metabolic deregulation of H

Indexed as

DysbiosisFecesGastrointestinal MicrobiomeHydrogen SulfideRenal Insufficiency, ChronicAdultAgedAlanineBacteriaCase-Control StudiesFemaleHumansMaleMiddle AgedRenal DialysisSulfidesAlanineHydrogen SulfidelanthionineSulfidesChronic kidney diseaseDysbiosisGut microbiotaHemodialysisHydrogen sulfide (H2S)Kidney transplantLanthionine

Identifiers

PMID39462312
PMCPMC11515264

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.