Evidence map›Paper›PMID 39463206›Full record

ArticlePsychopharmacology2024

The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats.

Magdalena Zaniewska, Sabina Brygider, Iwona Majcher-Maślanka, Dawid Gawliński, Urszula Głowacka, Sława Glińska, Łucja Balcerzak

Abstract read
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In one paragraph

Article in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Magdalena ZaniewskaDepartment of Pharmacology and Brain Biostructure, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, Kraków, 31-343, Poland. zaniew@if-pan.krakow.pl.ORCID http://orcid.org/0000-0001-9716-6661
Sabina BrygiderDepartment of Pharmacology and Brain Biostructure, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, Kraków, 31-343, Poland.
Iwona Majcher-MaślankaDepartment of Pharmacology and Brain Biostructure, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, Kraków, 31-343, Poland.ORCID http://orcid.org/0000-0001-9449-5582
Dawid GawlińskiDepartment of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12 Street, Kraków, 31-343, Poland.ORCID http://orcid.org/0000-0002-9376-0564
Urszula GłowackaDepartment of Pharmacology and Brain Biostructure, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Street, Kraków, 31-343, Poland.ORCID http://orcid.org/0000-0002-1552-3117
Sława GlińskaFaculty of Biology and Environmental Protection, Laboratory of Microscopic Imaging and Specialized Biological Techniques, University of Lodz, Banacha 12/16, Lodz, 90-237, Poland.ORCID http://orcid.org/0000-0001-7202-7737
Łucja BalcerzakFaculty of Biology and Environmental Protection, Laboratory of Microscopic Imaging and Specialized Biological Techniques, University of Lodz, Banacha 12/16, Lodz, 90-237, Poland.

Funding

Narodowe Centrum Nauki 2015/17/B/NZ4/02621
6 · The paper itself

Abstract

rationaleThe literature indicates that nicotine exposure or its discontinuation impair adult hippocampal neurogenesis in rats, though the impact of exercise on this process remains unclear. We have previously shown that disturbances in the number of doublecortin (DCX, a marker of immature neurons)-positive (DCX

objectivesThis study aimed to investigate the effect of running on hippocampal neurogenesis, depression-like symptoms, and drug-seeking behaviour during nicotine deprivation.

methodsThe rats were subjected to nicotine (0.03 mg/kg/inf) self-administration via an increasing schedule of reinforcement. After 21 sessions, the animals entered a 14-day abstinence phase during which they were housed in either standard home cages without wheels, cages equipped with running wheels, or cages with locked wheels.

resultsWheel running increased the number of K

conclusionsIn summary, long-term wheel running positively affected the number of immature neurons in the hippocampus, which corresponded with an antidepressant response in nicotine-weaned rats. One possible mechanism underlying the positive effect of running on the affective state during nicotine cessation may be the reduction in deficits in DCX

Indexed as

Doublecortin ProteinHippocampusNeurogenesisNicotinePhysical Conditioning, AnimalSelf AdministrationAnimalsBehavior, AnimalDentate GyrusDepressionDoublecortin Domain ProteinsDrug-Seeking BehaviorMaleNeuropeptidesRatsRats, WistarDcx protein, ratDoublecortin Domain ProteinsDoublecortin ProteinNeuropeptidesNicotineDoublecortinHippocampal neurogenesisNicotine self-administrationRatWheel running

Identifiers

PMID39463206
PMCPMC11569017

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.