Evidence map›Paper›PMID 39463965›Full record

ArticlebioRxiv : the preprint server for biology2024

The restricted N-glycome of neurons is programmed during differentiation.

Katherine Kiwimagi, Maxence Noel, Murat Cetinbas, Ruslan I Sadreyev, Lei Wang, Jordan W Smoller, Richard D Cummings, Ron Weiss, Robert G Mealer

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katherine KiwimagiSynthetic Biology Center, Department of Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-5844-9412
Maxence NoelNational Center for Functional Glycomics, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2621-7374
Murat CetinbasDepartment of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lei WangSynthetic Biology Center, Department of Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-5218-556X
Jordan W SmollerPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0381-6334
Richard D CummingsNational Center for Functional Glycomics, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8918-5034
Ron WeissSynthetic Biology Center, Department of Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-0396-2443
Robert G MealerDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-5963-2836

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Protein-Glycan Interaction Resource at the National Center for Functional Glycomics (NCFG)R24GM137763 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICHARD D CUMMINGS · 2020 to 2026
$5.8M
Synaptic dysglycosylation caused by the schizophrenia-risk variant in SLC39A8K08MH128712 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEALER, ROBERT G · 2021 to 2024
$771k
NIDDK NIH HHS P30 DK040561NIGMS NIH HHS R24 GM137763NIMH NIH HHS K08 MH128712
6 · The paper itself

Abstract

The protein glycome of individual cell types in the brain is unexplored, despite the critical function of these modifications in development and disease. In aggregate, the most abundant asparagine (N-) linked glycans in the adult brain are high mannose structures, and specifically Man

Indexed as

GlycosylationiPSCsneuronsN-glycome

Identifiers

PMID39463965
PMCPMC11507760

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.