ArticlebioRxiv : the preprint server for biology2024
Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors.
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Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice.Psychopharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
57 authors.
Michael A KelbermanDepartment of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
Ellen RodbergDepartment of Biology, University of Massachusetts Amherst, Amherst, MA, USA.
Ehsan ArabzadehEccles Institute of Neuroscience, John Curtin School of Medical Research, The Australian National University, Canberra, AUS.ORCID 0000-0001-9632-0735
Chloe J Bair-MarshallNeuroscience Institute, NYU Langone Medical Center, New York University, New York, New York, USA.ORCID 0000-0001-6458-3266
Craig W BerridgeDepartment of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
Esther BerrocosoNeuropsychopharmacology and Psychobiology Research Group, Department of Neuroscience, School of Medicine, Biomedical Research and Innovation Institute of Cádiz (INiBICA), University of Cadiz, Cadiz, Spain.ORCID 0000-0003-0208-7472
Vincent Breton-ProvencherDepartment of Psychiatry and Neuroscience, Université Laval, Québec, QC, Canada.ORCID 0000-0002-1701-325X
Daniel J ChandlerDepartment of Neuroscience, Rowan-Virtua SOM, Stratford, NJ, USA.ORCID 0000-0002-5874-4307
Alicia CheDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Oscar DavySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
David M DevilbissDepartment of Neuroscience, Rowan-Virtua SOM, Stratford, NJ, USA.ORCID 0000-0002-7237-5720
Anthony M DownsBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-0146-4459
Gabrielle DrummondDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-9903-6211
Roman DvorkinCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0003-1586-2394
Zeinab FazlaliSchool of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.ORCID 0000-0002-6728-2992
Robert C FroemkeNeuroscience Institute, NYU Langone Medical Center, New York University, New York, New York, USA.
Erin GlennonNeuroscience Institute, NYU Langone Medical Center, New York University, New York, New York, USA.
Joshua I GoldDepartment of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6018-0483
Hiroki ItoSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-4433-370X
Xiaolong JiangDepartment of Neuroscience, Baylor College of Medicine Neurological Research Institute at Texas Children's Hospital, 1250, Houston, TX, USA.
Joshua P JohansenRIKEN Center for Brain Science, Wako-shi Saitama, Japan.
Alfred P KayeDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3153-1221
Jenny R KimDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-1393-7815
Chao-Cheng KuoDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-9332-2743
Rong-Jian LiuDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Yang LiuDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Meritxell Llorca-TorralbaNeuropsychopharmacology and Psychobiology Research Group, Department of Neuroscience, School of Medicine, Biomedical Research and Innovation Institute of Cádiz (INiBICA), University of Cadiz, Cadiz, Spain.ORCID 0000-0001-8447-928X
Jordan G McCallDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-8295-0664
Zoe A McElligottBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-4717-5698
Andrew M McKinneyDepartment of Neuroscience, Baylor College of Medicine Neurological Research Institute at Texas Children's Hospital, 1250, Houston, TX, USA.ORCID 0000-0003-4439-2264
Cristina MiguelezDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.ORCID 0000-0001-6624-2932
Ming-Yuan MinDepartment of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-4211-6725
Alexandra C NowlanBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-8543-119X
Mohsen OmraniDepartment of Psychiatry, Queen's University, Kingston, ON, Canada.ORCID 0000-0002-0461-1947
Gina R PoeIntegrative Biology and Physiology, UCLA, Los Angeles, CA, USA.
Anthony Edward PickeringSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.ORCID 0000-0003-0345-0456
Yadollah Ranjbar-SlamlooSchool of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Jone RazquinDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain.ORCID 0000-0001-7996-7895
Charles RodenkirchDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Anna C SalesSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.ORCID 0000-0001-8585-3763
Rath SatyasambitRIKEN Center for Brain Science, Wako-shi Saitama, Japan.ORCID 0000-0003-3834-7432
Stephen D SheaCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0001-6927-0189
Mriganka SurDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-2442-5671
John Arthur TkaczynskiDepartment of Neuroscience, Rowan-Virtua SOM, Stratford, NJ, USA.
Sonia Torres-SanchezNeuropsychopharmacology and Psychobiology Research Group, Department of Neuroscience, School of Medicine, Biomedical Research and Innovation Institute of Cádiz (INiBICA), University of Cadiz, Cadiz, Spain.ORCID 0000-0003-0255-6558
Akira UematsuHuman Informatics and Information Research Institute, National Institute of Advanced Industrial Science and Technology, Japan.ORCID 0000-0002-0679-2649
Chayla R VazquezDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-0077-9224
Amelien VrevenHelsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.
Qi WangDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0001-8656-1439
Barry D WaterhouseDepartment of Neuroscience, Rowan-Virtua SOM, Stratford, NJ, USA.
Hsiu-Wen YangDepartment of Biomedical Sciences, Chung-Shan Medical University, Taichung, Taiwan.
Jen-Hau YangDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Liping ZhaoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA USA.
Ioannis S ZouridisGraduate Training Centre of Neuroscience, International Max Planck Research School (IMPRS), University of Tübingen, Tübingen, Germany.ORCID 0000-0002-4032-3723
David WeinshenkerDepartment of Human Genetics, Emory University, Atlanta, GA, USA.
Elena VazeyDepartment of Biology, University of Massachusetts Amherst, Amherst, MA, USA.
Nelson K TotahHelsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0998-9770
Funding
U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2018 to 2026
$36.4MSupplement to Molecular and Cellular Studies on Alcohol's ActionsT32AA007573 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FULTON T CREWS, Thomas L. Kash · 1997 to 2026
$9.3MSynaptic basis of perceptual learning with cochlear implants in rat auditory cortex - RenewalR01DC012557 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Robert Crooks Froemke, Mario A Svirsky · 2013 to 2026
$7.0MMicroRNA mechanisms of Rett SyndromeR01MH085802 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2010 to 2025
$6.2MPDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse BladdersR01DK098361 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A, KANAI, ANTHONY JOHN · 2014 to 2024
$5.7M4/8: INIA Stress and Chronic Alcohol Interactions: Impact of stress mediated locus coeruleus dysregulation on cognitive control and excessive drinkingU01AA025481 · NIAAA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI DAVID E MOORMAN, Elena Vazey · 2017 to 2026
$4.2MTraining In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9MVISUAL SCIENCEST32EY007001 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$3.7MDeciphering the building blocks of hippocampal circuitsR01MH109556 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI SANDBERG, RICKARD, TOLIAS, ANDREAS · 2017 to 2021
$3.3MMechanisms underlying selective vulnerability of locus coeruleus neurons in Alzheimer's diseaseRF1AG061175 · NIA · EMORY UNIVERSITY · PI KANG, SEONG SU, WEINSHENKER, DAVID · 2019 to 2019
$2.8MNeuron-astrocyte mechanisms of norepinephrine in goal-directed learningR01MH133066 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MRIGANKA SUR · 2023 to 2026
$2.6MEmotional modulation of neural and behavioral responses to social cues by locus coeruleusR01MH119250 · NIMH · COLD SPRING HARBOR LABORATORY · PI SHEA, STEPHEN D · 2019 to 2023
$2.4MNEI NIH HHS T32 EY007001NIAAA NIH HHS T32 AA007573NIAAA NIH HHS U01 AA025481NIA NIH HHS F31 AG069502NIA NIH HHS R01 AG062581NIA NIH HHS RF1 AG061175NIA NIH HHS RF1 AG079199NIDA NIH HHS R01 DA049261NIDA NIH HHS R01 DA059378NIDCD NIH HHS F30 DC017351NIDCD NIH HHS R01 DC012557NIDDK NIH HHS R01 DK098361NIMH NIH HHS F31 MH129112NIMH NIH HHS F31 MH131348NIMH NIH HHS K08 MH122733NIMH NIH HHS R00 MH104716NIMH NIH HHS R01 MH085802NIMH NIH HHS R01 MH109556NIMH NIH HHS R01 MH112267NIMH NIH HHS R01 MH119250NIMH NIH HHS R01 MH126351NIMH NIH HHS R01 MH133066NIMH NIH HHS R21 MH093904NIMH NIH HHS R21 MH125107NIMH NIH HHS R21 MH134183NIMH NIH HHS R56 MH121918NINDS NIH HHS R01 NS101596NINDS NIH HHS R01 NS117899NINDS NIH HHS R01 NS119813NINDS NIH HHS R34 NS123876NINDS NIH HHS T32 NS096050NINDS NIH HHS U19 NS107616Wellcome Trust
Abstract
The brainstem region, locus coeruleus (LC), has been remarkably conserved across vertebrates. Evolution has woven the LC into wide-ranging neural circuits that influence functions as broad as autonomic systems, the stress response, nociception, sleep, and high-level cognition among others. Given this conservation, there is a strong possibility that LC activity is inherently similar across species, and furthermore that age, sex, and brain state influence LC activity similarly across species. The degree to which LC activity is homogenous across these factors, however, has never been assessed due to the small sample size of individual studies. Here, we pool data from 20 laboratories (1,855 neurons) and show diversity across both intrinsic and extrinsic factors such as species, age, sex and brain state. We use a negative binomial regression model to compare activity from male monkeys, and rats and mice of both sexes that were recorded across brain states from brain slices
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.