Evidence map›Paper›PMID 39464039›Full record

ArticlebioRxiv : the preprint server for biology2024

ISWI chromatin remodeler SMARCA5 is essential for meiotic gene expression and male fertility in mammals.

Shubhangini Kataruka, Aushaq B Malla, Shannon R Rainsford, Bluma J Lesch

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Shubhangini KatarukaDepartment of Genetics, Yale School of Medicine, New Haven CT USA 06510.ORCID 0000-0002-1303-6390
Aushaq B MallaDepartment of Genetics, Yale School of Medicine, New Haven CT USA 06510.ORCID 0000-0001-5733-6523
Shannon R RainsfordDepartment of Genetics, Yale School of Medicine, New Haven CT USA 06510.
Bluma J LeschDepartment of Genetics, Yale School of Medicine, New Haven CT USA 06510.ORCID 0000-0002-6689-0240

Funding

GENETICS AND GENOMICS OF HUMAN DISEASET32HD007149 · NICHD · YALE UNIVERSITY · PI James P Noonan · 1985 to 2026
$8.2M
Germline Utx mutation as a model for transgenerational epigenetic inheritanceR01HD098128 · NICHD · YALE UNIVERSITY · PI LESCH, BLUMA J · 2020 to 2024
$2.0M
Defining the role of DOT1L in chromocenter stabilization pre- and post-fertilizationR21HD110843 · NICHD · YALE UNIVERSITY · PI LESCH, BLUMA J · 2023 to 2023
$461k
Defining signatures of epigenetic sensitization to lung cancer in a mouse modelR21CA288677 · NCI · YALE UNIVERSITY · PI LESCH, BLUMA J · 2024 to 2025
$430k
NCI NIH HHS R21 CA288677NICHD NIH HHS R01 HD098128NICHD NIH HHS R21 HD110843NICHD NIH HHS T32 HD007149
6 · The paper itself

Abstract

Regulation of the transcriptome to promote meiosis is important for sperm development and fertility. However, how chromatin remodeling directs the transcriptome during meiosis in male germ cells is largely unknown. Here, we demonstrate that the ISWI family ATP-dependent chromatin remodeling factor SMARCA5 (SNF2H) plays a critical role in regulating meiotic prophase progression during spermatogenesis. Males with germ cell-specific depletion of SMARCA5 are infertile and unable to form sperm. Loss of

Identifiers

PMID39464039
PMCPMC11507727

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.