Evidence map›Paper›PMID 39464045›Full record

ArticlebioRxiv : the preprint server for biology2024

Richard G Held, Jiahao Liang, Luis Esquivies, Yousuf A Khan, Chuchu Wang, Maia Azubel, Axel T Brunger

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Richard G HeldDepartment of Molecular and Cellular Physiology; Stanford University, Stanford, United States.ORCID 0000-0001-8231-0341
Jiahao LiangDepartment of Molecular and Cellular Physiology; Stanford University, Stanford, United States.ORCID 0000-0002-6701-4808
Luis EsquiviesDepartment of Molecular and Cellular Physiology; Stanford University, Stanford, United States.ORCID 0000-0002-1750-6775
Yousuf A KhanDepartment of Molecular and Cellular Physiology; Stanford University, Stanford, United States.ORCID 0000-0003-0201-2796
Chuchu WangDepartment of Molecular and Cellular Physiology; Stanford University, Stanford, United States.ORCID 0000-0003-2015-7331
Maia AzubelHoward Hughes Medical Institute; Stanford University, Stanford, United States.ORCID 0000-0002-1584-2695
Axel T BrungerDepartment of Molecular and Cellular Physiology; Stanford University, Stanford, United States.ORCID 0000-0001-5121-2036

Funding

Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC) SupplementU24GM139166 · NIGMS · STANFORD UNIVERSITY · PI Wah Chiu · 2020 to 2026
$11.7M
STRUCTURE OF PROTEINS INVOLVED IN SYNAPTIC EXOCYTOSISR01MH063105 · NIMH · STANFORD UNIVERSITY · PI BRUNGER, AXEL T · 2000 to 2025
$4.7M
Nikon A1Rsi resonant spectral confocal microscopeS10OD010580 · OD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2013 to 2013
$377k
NIGMS NIH HHS U24 GM139166NIH HHS S10 OD010580NIMH NIH HHS R01 MH063105
6 · The paper itself

Abstract

Most synapses in the brain transmit information by the presynaptic release of vesicular glutamate, driving postsynaptic depolarization through AMPA-type glutamate receptors (AMPARs). The nanometer-scale topography of synaptic AMPARs regulates response amplitude by controlling the number of receptors activated by synaptic vesicle fusion. The mechanisms controlling AMPAR topography and their interactions with postsynaptic scaffolding proteins are unclear, as is the spatial relationship between AMPARs and synaptic vesicles. Here, we used cryo-electron tomography to map the molecular topography of AMPARs and visualize their

Identifiers

PMID39464045
PMCPMC11507944

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.