Evidence map›Paper›PMID 39464097›Full record

ArticlebioRxiv : the preprint server for biology2024

Factors Promoting Lipopolysaccharide Uptake by Synthetic Lipid Droplets.

Assame Arnob, Anirudh Gairola, Hannah Clayton, Arul Jayaraman, Hung-Jen Wu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Assame ArnobArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.
Anirudh GairolaArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.
Hannah ClaytonArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.
Arul JayaramanArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.
Hung-Jen WuArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.

Funding

NIAID NIH HHS R03 AI139650
6 · The paper itself

Abstract

Lipoproteins are essential in removing lipopolysaccharide (LPS) from blood during bacterial inflammation. The physicochemical properties of lipoproteins and environmental factors can impact LPS uptake. In this work, synthetic lipid droplets containing triglycerides, cholesterols, and phospholipids, were prepared to mimic lipoproteins. The physicochemical properties of these lipid droplets, such as charges, sizes, and lipid compositions, were altered to understand the underlying factors affecting LPS uptake. The amphiphilic LPS could spontaneously adsorb on the surface of lipid droplets without lipopolysaccharide binding protein (LBP); however, the presence of LBP can increase LPS uptake. The positively charged lipid droplets also enhance the uptake of negatively charged LPS. Most interestingly, the LPS uptake highly depends on the concentrations of Ca

Indexed as

CalciumLipopolysaccharideLipopolysaccharide binding proteinLipoproteinSepsisSynthetic lipid droplets

Identifiers

PMID39464097
PMCPMC11507836

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.