Evidence map›Paper›PMID 39464100›Full record

ArticlebioRxiv : the preprint server for biology2024

Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human Disease.

Muzi Du, Suleyman C Akerman, Charlotte M Fare, Linhao Ruan, Svetlana Vidensky, Lyudmila Mamedova, Joshua Lee, Jeffrey D Rothstein

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Muzi DuDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Suleyman C AkermanBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Charlotte M FareBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Linhao RuanBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Svetlana VidenskyBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Lyudmila MamedovaBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Joshua LeeDepartment of Psychological and Brain Sciences, Johns Hopkins University Krieger School of Arts and Sciences, Baltimore, MD, 21218, USA.
Jeffrey D RothsteinDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0003-2001-8470

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI BANDEEN-ROCHE, KAREN J. · 1985 to 2019
$37.6M
Nuclear and Glial Dysfunction in NeurodegenerationR35NS132179 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Jeffrey D Rothstein · 2023 to 2026
$4.9M
NIA NIH HHS P50 AG005146NINDS NIH HHS R35 NS132179
6 · The paper itself

Abstract

TMEM106B is a lysosomal/late endosome protein that is a potent genetic modifier of multiple neurodegenerative diseases as well as general aging. Recently, TMEM106B was shown to form insoluble aggregates in postmortem human brain tissue, drawing attention to TMEM106B pathology and the potential role of TMEM106B aggregation in disease. In the context of neurodegenerative diseases, TMEM106B has been studied

Indexed as

Alzheimer’s diseaseamyotrophic lateral sclerosisfrontotemporal dementiamurine models of neurodegenerative diseaseneurodegenerative diseasepathologyTAR DNA-binding protein 43tauopathyTMEM106B

Identifiers

PMID39464100
PMCPMC11507888

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.