Dietary acid load adopts the effect of ApoB ins/del genetic variant (rs11279109) on obesity trait, cardiovascular markers, lipid profile, and serum leptin level among patients with diabetes: a cross-sectional study.

Zahra Esmaeily, Faezeh Abaj, Zeinab Naeini, Ehsan Alvandi, Masoumeh Rafiee, Fariba Koohdani

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Zahra EsmaeilyDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Faezeh AbajDepartment of nutrition, Dietetics and Food, School of Clinical Sciences at Monash Health, Monash University, Clayton, Australia.

Zeinab NaeiniDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, PO Box: 141556117, Tehran, Iran.

Ehsan AlvandiSchool of Medicine, Western Sydney University, Campbelltown, NSW, Australia.

Masoumeh Rafiee *Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran. masomeh.rafiei@gmail.com.

Fariba Koohdani *Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, PO Box: 141556117, Tehran, Iran. fkoohdan@tums.ac.ir.

Funding

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6 · The paper itself

Abstract

ApoB insertion/deletion (ins/del) genetic variant (rs11279109) is thought to be related to cardio-metabolic markers and obesity. This association has the potential to be modified by dietary patterns. Since the majority of studies concerned the role of dietary acid load (DAL) or ApoB in type 2 diabetes mellitus (T2DM) and its complications independently, and due to the insufficient data regarding the possible interactions between ApoB genetic variants and DAL on anthropometric and metabolic markers, we aimed to study the interaction between this genetic variant and dietary acid load (DAL) on cardio-metabolic markers, along with leptin among Iranian individuals with T2DM. 700 T2DM patients were randomly recruited. A validated semi-quantitative food frequency questionnaire was used for DAL calculation including potential renal acid load (PRAL) and net-endogenous acid production (NEAP). The polymerase chain reaction was used for genotyping the ApoB ins/del (rs11279109). The general linear model was applied to find the interactions in the crude and adjusted models. Patients with del/del genotype (rs11279109) with high PRAL intake have lower low-density lipoprotein cholesterol (LDL-C) (P

Indexed as

Diabetes Mellitus, Type 2LeptinObesityAcidsAdultAgedApolipoprotein B-100Apolipoproteins BBiomarkersCross-Sectional StudiesDietFemaleGenotypeHumansINDEL MutationIranAcidsAPOB protein, humanApolipoprotein B-100Apolipoproteins BBiomarkersLeptinLipidsApoBDietary acid loadGenetic variantInflammationLipid profileObesity

Identifiers

PMID39465244

DOI10.1038/s41598-024-75352-x

PMCPMC11514203

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LicenceCC BY-NC-ND

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