Evidence map›Paper›PMID 39465362›Full record

ArticleBMC pediatrics2024

Prenatal risk factors for child executive function at 3-5 years of age: the roles of maternal mood, substance use, and socioeconomic adversity in a prospective cohort study.

Yael K Rayport, Santiago Morales, Lauren C Shuffrey, Christine W Hockett, Katherine Ziegler, Shreya Rao, William P Fifer, Amy J Elliott, Ayesha Sania

Abstract read
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In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yael K RayportDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Santiago MoralesDepartment of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.
Lauren C ShuffreyDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, 10016, USA.
Christine W HockettAvera Research Institute, Sioux Falls, SD, 57108, USA.
Katherine ZieglerAvera Research Institute, Sioux Falls, SD, 57108, USA.
Shreya RaoDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, 10032, USA.
William P FiferDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, 10032, USA.
Amy J ElliottAvera Research Institute, Sioux Falls, SD, 57108, USA.
Ayesha SaniaDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, 10032, USA. as4823@cumc.columbia.edu.

Funding

Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study CohortsUH3OD023279 · OD · AVERA MCKENNAN · PI Amy J Elliott, Christine W Hockett · 2018 to 2026
$31.7M
NIH HHS UH3 OD023279NIH Office of the Director UH3OD023279NIH Office of the Director UH3OD023279-05S1
6 · The paper itself

Abstract

backgroundA growing body of literature links prenatal mood and substance use to children's cognitive and behavioral development. The relative contribution of these risk factors on children's executive function (EF) in the context of socioeconomic adversities needs further evaluation. To address this gap, we investigated the role of prenatal maternal anxiety and depression on childhood EF, specifically inhibitory control and working memory, within the context of socioeconomic adversities and prenatal substance use. We hypothesized that higher maternal mood symptoms, higher persistent prenatal drinking and smoking, and lower socioeconomic status would be associated with lower EF skills during early childhood.

methodsWe used data from 334 mother-child dyads followed prospectively through pregnancy and the offspring's childhood. Prenatal maternal depression and anxiety were assessed via standardized questionnaires. Prenatal alcohol and tobacco consumption were assessed via a timeline follow-back interview. The EF touch battery assessed child inhibitory control and working memory at 3-5 years of age (4.76 ± 0.58 years, 171 females). Separate linear regression models were used to estimate the association of prenatal tobacco, alcohol, anxiety, and depression exposure with our two components of child EF, inhibitory control and working memory, while adjusting for gestational age, sex, and age at assessment. The following variables were also included as covariates: maternal educational achievement, employment status, parity, and household crowding index.

resultsChildren of mothers with high trait anxiety scores had reduced inhibitory control compared to children of mothers without trait anxiety or depression (β = -0.12, 95% CI:-0.22,-0.01). Children of mothers in the moderate to high continuous smoking group showed lower inhibitory control (β = - 0.19, 95% CI:-0.38,-0.01) compared to children of mothers in the none smoking group. Additionally, lower maternal education and higher household crowding were each associated with reduced inhibitory control. We found no significant association between prenatal maternal depression, anxiety, or socioeconomic factors with working memory.

conclusionsThese results underscore the need for comprehensive context-specific intervention packages, including mental health support for women to promote healthy inhibitory control development in children.

Indexed as

DepressionExecutive FunctionMemory, Short-TermPrenatal Exposure Delayed EffectsAdultAffectAlcohol DrinkingAnxietyChild, PreschoolFemaleHumansInhibition, PsychologicalMaleMothersPregnancyPregnancy ComplicationsEF touch batteryExecutive functionPrenatal alcohol and tobacco exposurePrenatal anxietyPrenatal depressionSocioeconomic adversity

Identifiers

PMID39465362
PMCPMC11514844

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.