Evidence map›Paper›PMID 39467609›Full record

Trial reportThe European respiratory journal2025

ECG-based risk factors for adverse cardiopulmonary events and treatment outcomes in COPD.

R Chad Wade, Fernando J Martinez, Gerard J Criner, Lee Tombs, David A Lipson, David M G Halpin, MeiLan K Han, Dave Singh, Robert A Wise, Ravi Kalhan and 1 more

Abstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

R Chad WadeDivision of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Fernando J MartinezDivision of Pulmonology and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
Gerard J CrinerLewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Lee TombsPrecise Approach Ltd, London, UK.
David A LipsonGSK, Collegeville, PA, USA.ORCID https://orcid.org/0000-0001-6732-4593
David M G HalpinUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID https://orcid.org/0000-0003-2009-4406
MeiLan K HanUniversity of Michigan, Ann Arbor, MI, USA.
Dave SinghCentre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester University NHS Foundation Trust, Manchester, UK.
Robert A WiseJohns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-8353-2349
Ravi KalhanDepartment of Preventive Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Mark T DransfieldDivision of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA mdransfield@uabmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOPD has high mortality, compounded by comorbid cardiovascular disease. We investigated two ECG markers, Cardiac Infarction Injury Score (CIIS) and P pulmonale, as prognostic tools for adverse cardiopulmonary events in COPD.

methodsThis was a

resultsWe included 9448 patients. Patients with CIIS ≥20 (

conclusionsThese findings suggest the potential clinical relevance of CIIS and P pulmonale as risk indicators for adverse cardiopulmonary events in COPD.

Indexed as

Cardiovascular DiseasesElectrocardiographyMyocardial InfarctionPulmonary Disease, Chronic ObstructiveAgedAndrostadienesBenzyl AlcoholsBronchodilator AgentsChlorobenzenesFemaleHospitalizationHumansMaleMiddle AgedOdds RatioPrognosisAndrostadienesBenzyl AlcoholsBronchodilator AgentsChlorobenzenesfluticasone furoateGSK573719Quinuclidinesvilanterol

Identifiers

PMID39467609
PMCPMC11799883

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.