Evidence map›Paper›PMID 39467636›Full record

ArticleLife science alliance2025

Targeting TREM2 signaling shows limited impact on cerebrovascular calcification.

Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Keller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sucheta SridharDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-2699-0367
Yingyue ZhouDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-0923-1046
Adiljan IbrahimAlector, South San Francisco, CA, USA.
Sergio BertazzoDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID 0000-0003-4889-8190
Tania WyssTDS-facility, AGORA Cancer Research Center, Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID 0000-0003-2641-0895
Amanda SwainDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Upasana MaheshwariDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-7516-3099
Sheng-Fu HuangDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-6409-5470
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-5222-4987
Annika KellerDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland annika.keller@usz.ch.ORCID 0000-0003-1466-3633

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain calcification, the ectopic mineral deposits of calcium phosphate, is a frequent radiological finding and a diagnostic criterion for primary familial brain calcification. We previously showed that microglia curtail the growth of small vessel calcification via the triggering receptor expressed in myeloid 2 (TREM2) in the

Indexed as

Disease Models, AnimalMembrane GlycoproteinsMicrogliaReceptors, ImmunologicSignal TransductionVascular CalcificationAnimalsBrainCerebrovascular DisordersMaleMiceMice, Inbred C57BLMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouse

Identifiers

PMID39467636
PMCPMC11519321

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.