Evidence map›Paper›PMID 39467963›Full record

SynthesisHeart failure reviews2025

Sodium-glucose cotransporter-2 inhibitors in acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials.

Matheus Coelho Meine, Paula Santo, Fabiana Dolovitsch de Oliveira, Gustavo Lenci Marques, Joaquim Spadoni Barboza

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Heart failure reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matheus Coelho MeineSchool of Medicine, Pontifical Catholic University of Paraná, Curitiba, Brazil.
Paula SantoDiagnostic Imaging and Specialized Diagnosis Unit, University Hospital of Federal University of São Carlos, 111, Luís Vaz de Camões Street - Vila Celina, São Carlos, SP, 13566-448, Brazil. paulaaesanto@hotmail.com.
Fabiana Dolovitsch de OliveiraSchool of Medicine, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
Gustavo Lenci MarquesPostgraduate Program in Internal Medicine and Health Sciences, Federal University of Paraná, Curitiba, Brazil.
Joaquim Spadoni BarbozaDivision of Cardiology, University of Illinois, Chicago, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to assess the efficacy and safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) versus placebo, initiated within the hospitalization period, in addition to habitual treatment, for treating adult patients with confirmed acute myocardial infarction (AMI). We also conducted subgroup analysis by diabetes mellitus (DM) status and type of AMI. We systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials (RCTs). The primary outcome was hospitalization for heart failure (HF). The secondary outcomes were all-cause death, cardiovascular death, and serious adverse events (AEs). We pooled risk ratios (RR) with a 95% confidence interval (CI) for binary outcomes. The between-study variance was assessed using tau

Indexed as

Myocardial InfarctionRandomized Controlled Trials as TopicSodium-Glucose Transporter 2 InhibitorsDiabetes Mellitus, Type 2HospitalizationHumansTreatment OutcomeSodium-Glucose Transporter 2 InhibitorsAcute myocardial infarctionHeart failureMortalitySafetySodium-glucose cotransporter-2 inhibitors

Identifiers

PMID39467963

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.