Evidence map›Paper›PMID 39468349›Full record

ArticleNature chemical biology2025

Selective bioorthogonal probe for N-glycan hybrid structures.

Mana Mohan Mukherjee, Devin Biesbrock, Lara K Abramowitz, Matteo Pavan, Bhoj Kumar, Peter J Walter, Parastoo Azadi, Kenneth A Jacobson, John A Hanover

Abstract read
In one paragraph

Article in Nature chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Iterative Bump-and-Hole Engineering Creates a Bioorthogonal Reporter forJournal of the American Chemical Society · 2026
    Article
  3. PerturbingCells · 2026
    Article
  4. Article
  5. Iterative Bump-and-hole engineering creates a bioorthogonal reporter forbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mana Mohan MukherjeeLaboratory of Cell and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA.
Devin BiesbrockLaboratory of Cell and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA.
Lara K AbramowitzLaboratory of Cell and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA.
Matteo PavanMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, MD, USA.
Bhoj KumarComplex Carbohydrate Research Center, The University of Georgia, Athens, GA, USA.ORCID http://orcid.org/0000-0001-8311-7025
Peter J WalterClinical Mass Spectrometry Core, NIDDK, National Institutes of Health, Bethesda, MD, USA.
Parastoo AzadiComplex Carbohydrate Research Center, The University of Georgia, Athens, GA, USA.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8104-1493
John A HanoverLaboratory of Cell and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA. johnh@bdg8.niddk.nih.gov.ORCID http://orcid.org/0000-0002-3154-9878

Funding

Development Of P2Y Receptor LigandsZIADK031116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$8.9M
National Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2M
Targeted disruption the enzymes of O-GlcNAc cycling: Animal models of DiseaseZ01DK060101 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HANOVER, JOHN A. · 2007 to 2008
$744k
ROLE OF THE NUCLEAR ENVELOPE IN INTRACELLULAR PROTEIN SORTINGZ01DK060000 · NIDDK · DIABETES, DIGESTIVE, KIDNEY DISEASES · PI HANOVER, JOHN A. · 1995 to 2006
–
Intramural NIH HHS Z01 DK060000Intramural NIH HHS Z01 DK060101Intramural NIH HHS ZIA DK031116NIGMS NIH HHS R24 GM137782U.S. Department of Health & Human Services | National Institutes of Health (NIH) DK060101-18U.S. Department of Health & Human Services | National Institutes of Health (NIH) ZIADK031116U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R24GM137782
6 · The paper itself

Abstract

Metabolic incorporation of chemically tagged monosaccharides is a facile means of tagging cellular glycoproteins and glycolipids. However, since the monosaccharide precursors are often shared by several pathways, selectivity has been difficult to attain. For example, N-linked glycosylation is a chemically complex and ubiquitous posttranslational modification, with three distinct classes of GlcNAc-containing N-glycan structures: oligomannose, hybrid and complex. Here we describe the synthesis of 1,3-Pr

Indexed as

Molecular ProbesPolysaccharidesGlycoproteinsGlycosylationHumansGlycoproteinsMolecular ProbesPolysaccharides

Identifiers

PMID39468349
PMCPMC12288097

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.