Evidence map›Paper›PMID 39468528›Full record

ArticleJournal of nanobiotechnology2024

Magnetic targeting enhances the neuroprotective function of human mesenchymal stem cell-derived iron oxide exosomes by delivering miR-1228-5p.

Wei-Jia Hu, Hong Wei, Li-Li Cai, Yu-Hao Xu, Rui Du, Qun Zhou, Xiao-Lan Zhu, Yue-Feng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  12. The Role of Mitochondrial Complexes in Liver Diseases.Journal of clinical and translational hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei-Jia Hu *Department of Radiology, Affiliated People's Hospital of Jiangsu University, No. 8, Dianli Road, Zhenjiang, Jiangsu, 212001, China.
Hong Wei *Department of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, No. 20, Zhengdong Road, Zhenjiang, Jiangsu, 212001, China.
Li-Li Cai *Medical College of Jiangsu University, No. 301, XueFu Road, Zhenjiang, Jiangsu, 212001, China.
Yu-Hao XuDepartment of Radiology, Affiliated Hospital of Jiangsu University, No. 438, Jiefang Road, Zhenjiang, Jiangsu, 212001, China.
Rui DuMedical College of Jiangsu University, No. 301, XueFu Road, Zhenjiang, Jiangsu, 212001, China.
Qun ZhouDepartment of Radiology, Affiliated Hospital of Jiangsu University, No. 438, Jiefang Road, Zhenjiang, Jiangsu, 212001, China.
Xiao-Lan ZhuDepartment of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, No. 20, Zhengdong Road, Zhenjiang, Jiangsu, 212001, China. zxl2517@163.com.
Yue-Feng LiDepartment of Radiology, Affiliated People's Hospital of Jiangsu University, No. 8, Dianli Road, Zhenjiang, Jiangsu, 212001, China. jiangdalyf@163.com.

Funding

Jiangsu Provincial Key Research and Development Plan BE2021693Key Medical Research Project of Jiangsu Health Committee K2023078National Natural Science Foundation of China 82172838
6 · The paper itself

Abstract

backgroundTreating mitochondrial dysfunction is a promising approach for the treatment of post-stroke cognitive impairment (PSCI). HuMSC-derived exosomes (H-Ex) have shown powerful therapeutic effects in improving mitochondrial function, but the specific effects are unclear and its brain tissue targeting needs to be further optimized.

resultsIn this study, we found that H-Ex can improve mitochondrial dysfunction of neurons and significantly enhance the cognitive behavior performance of MCAO mice in OGD/R-induced SHSY5Y cells and MCAO mouse models. Based on this, we have developed an exosome delivery system loaded with superparamagnetic iron oxide nanoparticles (Spion-Ex) that can effectively penetrate the blood-brain barrier (BBB). The research results showed that under magnetic attraction, Spion-Ex can more effectively target the brain tissue and significantly improve mitochondrial function of neurons after stroke. Meanwhile, we further confirmed that miR-1228-5p is a key factor for H-Ex to improve mitochondrial function and cognitive behavior both in vivo and in vitro. The specific mechanism is that the increase of miR-1228-5p mediated by H-Ex can inhibit the expression of TRAF6 and activate the TRAF6-NADPH oxidase 1 (NOX1) pathway, thereby exerting protective effects against oxidative damage. More importantly, we found that under magnetic attraction, Spion-Ex exhibited excellent cognitive improvement effects by delivering miR-1228-5p.

conclusionsOur research found that H-Ex has a good therapeutic effect on PSCI by increasing the expression of miR-1228-5p in PSCI, while H-Ex loaded with Spion-Ex exhibited more excellent effects on improving mitochondrial function and cognitive impairment under magnetic attraction, which can be used as a novel strategy for the treatment of PSCI.

Indexed as

ExosomesMesenchymal Stem CellsMicroRNAsMitochondriaAnimalsBlood-Brain BarrierBrainDisease Models, AnimalHumansMagnetic Iron Oxide NanoparticlesMaleMiceMice, Inbred C57BLNeuronsNeuroprotective AgentsStrokeMicroRNAsNeuroprotective AgentsCognitive impairmentExosomesOxidative stressSuperparamagnetic iron oxide nanoparticles

Identifiers

PMID39468528
PMCPMC11514807

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.