Evidence map›Paper›PMID 39468537›Full record

ArticleBMC endocrine disorders2024

To analyse the correlation between UAER and eGFR and the risk factors for reducing eGFR in patients with type 2 diabetes.

Haihui Li, Lanwen Han, Xia Gao

Abstract read
In one paragraph

Article in BMC endocrine disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Haihui LiDepartment of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Workers' Stadium South Road, Hujialou Street, Chaoyang District, Beijing, 100020, China.
Lanwen HanDepartment of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Workers' Stadium South Road, Hujialou Street, Chaoyang District, Beijing, 100020, China.
Xia GaoDepartment of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Workers' Stadium South Road, Hujialou Street, Chaoyang District, Beijing, 100020, China. gaoxia_ggg@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyse the correlation between urinary albumin excretion rate (UAER) and estimated glomerular filtration rate (eGFR) and the risk factors for reducing eGFR in patients with type 2 diabetes mellitus (T2DM).

methodsA total of 431 T2DM patients admitted between January 2019 and March 2020 were selected and divided into two groups according to eGFR level. Comparing the differences between baseline data and clinical indicators, multivariate logistic regression was used to analyse the risk factors of eGFR reduction and to analyse the association between UAER and eGFR.

resultsIn total, 167 patients were included in the study group and 264 patients were included in the conventional group. The study group participants were older, had longer diabetes duration, and had higher fatty liver, peripheral vascular disease (PVD), hypertension prevalence, and mean body mass index (P < 0.05). The levels of various indicators were lower than those of the conventional group (P < 0. 05). Additionally, PVD, nocturnal systolic blood pressure, fatty liver, and beta-2-microglobulin (β 2-MG) were independent risk factors for eGFR decline, with high density lipoprotein (HDL) and fasting C-peptide (CP) as protective factors. There was no obvious correlation between UAER and eGFR.

conclusionPeripheral vascular disease, systolic blood pressure, fatty liver, and beta-2-microglobulin are risk factors for decreased eGFR levels in patients with T2DM, which should be applied for control DKD. HDL and fasting CP have important effects on maintaining eGFR, and blood pressure and fasting CP can be used as new targets for subsequent diabetic kidney disease treatment.

Indexed as

AlbuminuriaDiabetes Mellitus, Type 2Glomerular Filtration RateAgedBiomarkersDiabetic NephropathiesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRisk FactorsBiomarkersAssociationDiabetic kidney diseaseEsitimated glomerular filtration rateRisk factorsUrinary albumin excretion rate

Identifiers

PMID39468537
PMCPMC11514529

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.