ArticleJournal of orthopaedic surgery and research2024
Association of MRI-based knee osteoarthritis structural phenotypes with short-term structural progression and subsequent total knee replacement.
Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changes in knee outcome measures following later-stage exercise interventions implemented ≤ 12 weeks vs. > 12 weeks after total knee arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- No short term pain benefit of adding corticosteroids to periarticular analgesia after total knee arthroplasty: a prospective, double-blind, randomized controlled trial.Journal of orthopaedic surgery and research · 2026Trial
- Perioperative blood loss of sequential administration of hemocoagulase Agkistrodon and Tranexamic acid for primary total knee arthroplasty: a randomized controlled trial.Journal of orthopaedic surgery and research · 2025Trial
- Circulating sTLR4 and sTREM-1 in Knee Osteoarthritis: Associations with Study-Specific MRI-Defined Categories and Disease Burden.Journal of clinical medicine · 2026Article
- The Effect of the Coronal Alignment of Extension Stem on Component Displacement and Stress During Total Knee Arthroplasty: A Finite Element Study.Orthopaedic surgery · 2026Article
- Advances in heterogeneity and classification of osteoarthritis.Bone research · 2026Review
- Review
- Advances in cartilage imaging techniques.Nature reviews. Rheumatology · 2026Review
- Comparison of robot-assisted modified subvastus approach versus medial parapatellar approach in total knee arthroplasty: a retrospective cohort study.Journal of orthopaedic surgery and research · 2026Article
- Structured MOAKS-based MRI features for predicting medial joint space narrowing progression: a comparative osteoarthritis initiative study.Frontiers in physiology · 2026Article
- Analysis of independent risk factors for high hidden blood loss following total knee arthroplasty.PloS one · 2026Article
- High patient and surgeon satisfaction with ChatGPT-generated responses to real patient questions regarding total knee arthroplasty.Journal of orthopaedic surgery and research · 2025Article
- Cement and screw reconstruction for Rand type II bone defects during total knee arthroplasty: a retrospective clinical and radiographic evaluation.Journal of orthopaedic surgery and research · 2025Article
- A development of machine learning models to preoperatively predict insufficient clinical improvement after total knee arthroplasty.Journal of orthopaedic surgery and research · 2025Article
- Comparison of VTE prophylaxis agents on hemoglobin levels after total knee arthroplasty: a hospital information system-based observational study.Journal of orthopaedic surgery and research · 2025Observational
- Clinical safety and efficacy of simultaneous bilateral total knee arthroplasty in an Asian population: a propensity score-matched analysis.Journal of orthopaedic surgery and research · 2025Article
- Ankle alignment before and after total knee arthroplasty in patients with valgus knee deformity.Journal of orthopaedic surgery and research · 2025Article
- Robot-assisted total knee arthroplasty is more precise than conventional total knee arthroplasty in restoring knee, but not ankle alignment: a retrospective study based on imaging data.Journal of orthopaedic surgery and research · 2025Article
- A novel technique of intraoperative infiltration between posterior capsule and popliteal artery can reduce opioid consumption and blood loss in total knee arthroplasty surgery: an age- and gender-matched study.Journal of orthopaedic surgery and research · 2025Article
- Satisfied with the worst health outcomes or unsatisfied with the best: explaining the divergence between good patient-reported outcomes and low satisfaction and vice versa among knee arthroplasty patients - a retrospective cohort study.Journal of orthopaedic surgery and research · 2025Article
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13 authors.
Funding
Abstract
backgroundThe failure of disease-modifying osteoarthritis drugs (DMOADs) trials lies mainly in the heterogeneity of the disease, which calls for a more precise population with specific progression and outcomes. This study aimed to determine whether and which MRI-based structural phenotype of knee osteoarthritis (KOA) is associated with short-term structural progression and subsequent total knee replacement (TKR).
methodsA longitudinal study was conducted among participants with baseline Kellgren-Lawrence grade (KLG) ≥ 2 from the Osteoarthritis Initiative (OAI). The structural phenotypes at baseline were defined as subchondral bone, meniscus/cartilage and inflammatory phenotypes according to the MRI Osteoarthritis Knee Score (MOAKS). The primary outcome was the progression of structural abnormalities within 24 months and multivariable logistic regressions were applied to evaluate the associations. The secondary outcome was the incidence of TKR during 108 months. Cox regressions and Kaplan-Meier survival curves were used for the analysis.
resultsA total of 733 participants with KOA were finally included in our study, with 493 (67.3%) having the three main structural phenotypes. For the primary outcome, the subchondral bone phenotype (OR [95% CI]:1.71 [1.02, 2.83], 1.52 [1.06, 2.18], 1.65 [1.11, 2.42], respectively) and the inflammatory phenotype (OR [95% CI]: 1.69 [1.05, 2.74], 1.82 [1.31, 2.52], 2.15 [1.48, 3.14], respectively) were both associated with the short-term progression of joint space narrowing, osteophytes and sclerosis in 24 months, whereas the meniscus/cartilage phenotype was only associated with the progression of osteophytes and sclerosis. For the secondary outcome, the subchondral bone phenotype (HR [95% CI]: 1.71 [1.06-2.78]) and inflammatory phenotype (HR [95%CI]: 2.00 [1.02-2.67]) were associated with shorter time to subsequent TKR, but not the meniscus/cartilage phenotype. Besides, the cumulative effect when the structural phenotype overlapped was confirmed in both outcomes.
conclusionsThe subchondral bone phenotype and inflammatory phenotype were associated with the progression of joint space narrowing, osteophytes and sclerosis in 24 months, along with subsequent TKR in 108 months. Besides, additive effects of overlapped phenotypes were further determined. These phenotypes could serve as valuable screening tools for future clinical trials and provide guidance for risk evaluation.
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