Evidence map›Paper›PMID 39468663›Full record

ArticleVirology journal2024

Epidemiology and genetic diversity of human respiratory syncytial virus in Belgium between 2011 and 2019.

Kaat Ramaekers, Els Keyaerts, Lieselot Houspie, Kurt Beuselinck, Marijke Reynders, Katrien Lagrou, Marc Van Ranst, Annabel Rector

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaat RamaekersLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49 Box 1040, 3000, Leuven, Belgium. kaat.ramaekers@gmail.com.
Els KeyaertsLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49 Box 1040, 3000, Leuven, Belgium.
Lieselot HouspieLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49 Box 1040, 3000, Leuven, Belgium.
Kurt BeuselinckDepartment of Laboratory Medicine, National Reference Centre for Respiratory Pathogens, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.
Marijke ReyndersUnit of Molecular Microbiology, Medical Microbiology, Department of Laboratory Medicine, Algemeen Ziekenhuis Sint-Jan, 3000, Brugge, Belgium.
Katrien LagrouDepartment of Laboratory Medicine, National Reference Centre for Respiratory Pathogens, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.
Marc Van RanstLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49 Box 1040, 3000, Leuven, Belgium.
Annabel RectorLaboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49 Box 1040, 3000, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman respiratory syncytial virus (HRSV) is worldwide one of the leading causes of acute respiratory tract infections in young children and the elderly population. Two distinct subtypes of HRSV (A and B) and a multitude of genotypes have been described. The laboratory of Clinical and Epidemiological Virology (KU Leuven/University Hospitals Leuven) has a long-standing history of HRSV surveillance in Belgium.

methodsIn this study, the seasonal circulation of HRSV in Belgium was monitored during 8 consecutive seasons prior to the SARS-CoV-2 pandemic (2011-2012 until 2018-2019). By use of a multiplex quantitative real time PCR panel, 27,386 respiratory samples were tested for HRSV. Further subtyping and sequencing of the HRSV positive samples was performed by PCR and Sanger sequencing. The prevalence and positivity rate were estimated in 4 distinct age groups and the circulating strains of each subtype were situated in a global context and in reference to the described genotypes in literature.

resultsHRSV circulated in Belgium in a yearly re-occurring pattern during the winter months and both HRSV subtypes co-circulated simultaneously. All HRSV-B strains contained the 60 nt duplication in the HVR2 region of the G gene. Strains of subtype HRSV-A with a 72 nt duplication in the HVR2 region were first observed during the 2011-2012 season and replaced all other circulating strains from 2014 to 2015 onwards.

Indexed as

Genetic VariationGenotypePhylogenyRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsSeasonsAdolescentAdultAgedAged, 80 and overBelgiumChildChild, PreschoolFemaleHumansInfantBelgiumEpidemiologyHuman respiratory syncytial virusRespiratory healthSeasonality

Identifiers

PMID39468663
PMCPMC11520483

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.