ArticleFluids and barriers of the CNS2024
Phase-contrast MRI analysis of cerebral blood and CSF flow dynamic interactions.
Article in Fluids and barriers of the CNS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cerebral Blood and Cerebrospinal Fluid Flow Dynamics in Endurance Athletes: Associations With Aortic Recoil and Heart Rate.Scandinavian journal of medicine & science in sports · 2026Article
- Variability in the circulation of cerebrospinal fluid: causes and clinical implications for intraventricular drug delivery.Frontiers in drug delivery · 2026Review
- Arterial-related craniospinal physiological compliance assessed by phase-contrast MRI and lumbar infusion test.Brain communications · 2026Article
- External Ventricular Drain Column Height Fails to Explain Cerebrospinal Fluid Drainage Volumes.Nursing in critical care · 2025Observational
- Synchronous quantification of arterial, venous, and cerebrospinal fluid flow dynamics using real-time phase-contrast MRI.Fluids and barriers of the CNS · 2025Article
- AI-Augmented Quantitative MRI Predicts Spontaneous Intracranial Hypotension.Diagnostics (Basel, Switzerland) · 2025Article
- Fluid dynamics model of the cerebral ventricular system.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- U-Net-Based Prediction of Cerebrospinal Fluid Distribution and Ventricular Reflux Grading.NMR in biomedicine · 2025Article
- The pulsing brain: state of the art and an interdisciplinary perspective.Interface focus · 2025Review
- Simultaneous and synchronous characterization of blood and CSF flow dynamics using multiple Venc PC MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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5 authors.
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Abstract
backgroundFollowing the Monro-Kellie doctrine, the Cerebral Blood Volume Changes (CB_VC) should be mirrored by the Cerebrospinal Fluid Volume Changes (CSF_VC) at the spinal canal. Cervical level is often chosen to estimate CB_VC during the cardiac cycle. However, due to the heterogeneity in the anatomy of extracranial internal jugular veins and their high compliance, we hypothesize that the intracranial level could be a better choice to investigate blood and cerebrospinal fluid (CSF) interactions. This study aims to determine which level, intracranial or extracranial, is more suitable for measuring arterial and venous flows to study cerebral blood and CSF dynamics interactions.
methodsThe spinal CSF and cerebral blood flow measured at intracranial and extracranial levels were quantified using cine phase-contrast magnetic resonance imaging (PC-MRI) in 38 healthy young adults. Subsequently, CSF_VC and CB_VC were calculated, and by linear regression analysis (R
resultsThe CB_VC amplitude was significantly higher at the extracranial level (0.89 ± 0.28 ml/CC) compared to the intracranial level (0.73 ± 0.19 ml/CC; p < 0.001). CSF oscillations through the spinal canal do not completely balance blood volume changes. The R
conclusionOur results confirmed that CSF does not completely and instantaneously balance cerebral blood expansion during the cardiac cycle. Nevertheless, the resting volume is very small compared to the total intracranial volume. To our knowledge, this study is the first to demonstrate these findings using cerebral blood flow measured intracranially below the Circle of Willis. Additionally, our findings show that cerebral arterial and venous flow dynamic measurements during the cardiac cycle obtained by PC-MRI at the intracranial plane strongly correlate with CSF oscillations measured in the spinal canal. Therefore, the intracranial vascular plane is more relevant for analyzing cerebral blood and CSF interactions during the cardiac cycle compared to measurements taken at the cervical vascular level.
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