Evidence map›Paper›PMID 39468832›Full record

Trial reportThe British journal of nutrition2026

Evaluation of a probiotic blend on psychosocial health and biomarkers of inflammatory, immune and stress response in adults with subthreshold depression: a double-blind, randomised, placebo-controlled trial.

George Moschonis, Katerina Sarapis, Stephanie Resciniti, Renate Hall, Kanny Yim, Matilda Tonkovic, Clare Fitzgerald, Fay Anixiadis, Antony Vinh, Quynh Nhu Dinh and 6 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

George MoschonisDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.ORCID https://orcid.org/0000-0003-3009-6675
Katerina SarapisDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.ORCID https://orcid.org/0000-0002-3397-8588
Stephanie RescinitiDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.
Renate HallDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.
Kanny YimDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.
Matilda TonkovicDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.
Clare FitzgeraldDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.
Fay AnixiadisDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.
Antony VinhCentre for Cardiovascular Biology and Disease Research (CCBDR), La Trobe Institute of Medical Science (LIMS), La Trobe University, Melbourne, VIC3086, Australia.
Quynh Nhu DinhCentre for Cardiovascular Biology and Disease Research (CCBDR), La Trobe Institute of Medical Science (LIMS), La Trobe University, Melbourne, VIC3086, Australia.
Rachael A CroninDepartment of Psychology, Counselling and Therapy, La Trobe University, Albury Wodonga, VIC3690, Australia.
Matthew W HaleDepartment of Psychology, Counselling and Therapy, La Trobe University, Melbourne, VIC3086, Australia.
Bradley J WrightDepartment of Psychology, Counselling and Therapy, La Trobe University, Melbourne, VIC3086, Australia.
Marco PaneProbiotical Research srl, Novara, 28100, Italy.
Caroline J TuckDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.
Jessica R BiesiekierskiDiscipline of Food, Nutrition and Dietetics, Department of Sport, Exercise and Nutrition Sciences, School Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC3086, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined the efficacy of a probiotic in reducing depressive symptom severity in people with subthreshold depression. In a double-blind, randomised, placebo-controlled trial, a probiotic (1 × 10^9 live cells per strain:

Indexed as

DepressionProbioticsStress, PsychologicalAdultAntioxidantsBiomarkersC-Reactive ProteinDouble-Blind MethodFemaleHumansHydrocortisoneInflammationMaleMiddle AgedYoung AdultAntioxidantsBiomarkersC-Reactive ProteinHydrocortisoneAnxietyDepressionLactobacillusProbioticsSubthreshold depression

Identifiers

PMID39468832
PMCPMC13161528

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.