Evidence map›Paper›PMID 39470949›Full record

ArticleBiomechanics and modeling in mechanobiology2025

A multiphasic model for determination of mouse ascending thoracic aorta mass transport properties with and without aneurysm.

Keshav A Kailash, Shamimur R Akanda, Alexandra L Davis, Christie L Crandall, Luis A Castro, Lori A Setton, Jessica E Wagenseil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Transport across the thoracic aortic wall: implications for aneurysm pathobiology, diagnosis, and treatment.American journal of physiology. Heart and circulatory physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Keshav A KailashDepartment of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Shamimur R AkandaDepartment of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Alexandra L DavisDepartment of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Christie L CrandallDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, USA.
Luis A CastroDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, USA.
Lori A SettonDepartment of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Jessica E WagenseilDepartment of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, USA. jessica.wagenseil@wustl.edu.

Funding

Theranostic approach to treat abdominal aortic aneurysmsR01HL133662 · NHLBI · CLEMSON UNIVERSITY · PI Naren R Vyavahare · 2017 to 2026
$4.1M
Intervertebral Disc Degeneration and Cross-Talk with the Nervous System - NOSI Diversity SupplementR01AR077678 · NIAMS · WASHINGTON UNIVERSITY · PI SETTON, LORI A., TANG, SIMON YUE-CHEONG · 2020 to 2024
$3.7M
Complementary animal and computational models for biomarker identification in ascending thoracic aortic aneurysmR01HL164800 · NHLBI · WASHINGTON UNIVERSITY · PI VICTOR H BAROCAS, Jessica Wagenseil · 2022 to 2026
$3.2M
Investigating altered smooth muscle cell mechanotransduction as a cause of supravalvular aortic stenosisR01HL166448 · NHLBI · WASHINGTON UNIVERSITY · PI Jessica Wagenseil · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL133662NHLBI NIH HHS R01 HL164800NHLBI NIH HHS R01 HL166448NIAMS NIH HHS R01 AR077678NIH HHS R01AR07767804NIH HHS R01HL133662
6 · The paper itself

Abstract

Thoracic aortic aneurysms (TAAs) are associated with aortic wall remodeling that affects transmural transport or the movement of fluid and solute across the wall. In previous work, we used a Fbln4

Indexed as

Aorta, ThoracicAortic Aneurysm, ThoracicModels, CardiovascularAnimalsBiological TransportDextransDisease Models, AnimalMiceMice, Inbred C57BLPermeabilityDextransBiphasicEffective diffusivityElastic fibersHydraulic permeabilityMixture theoryMultiphasic

Identifiers

PMID39470949
PMCPMC12118496

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.