Evidence map›Paper›PMID 39472297›Full record

ArticleInternational journal of cancer2025

ARP2/3 complex affects myofibroblast differentiation and migration in pancreatic ductal adenocarcinoma.

Yifeng Sun, Yina Qiao, Yiqi Niu, Bindhu Kollivayal Madhavan, Chao Fang, Jingxiong Hu, Kathleen Schuck, Benno Traub, Helmut Friess, Ingrid Herr and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yifeng SunDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Yina QiaoDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Yiqi NiuDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Bindhu Kollivayal MadhavanDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Chao FangDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Jingxiong HuDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Kathleen SchuckDepartment of General and Visceral Surgery, Ulm University Hospital, Ulm, Germany.
Benno TraubDepartment of General and Visceral Surgery, Ulm University Hospital, Ulm, Germany.
Helmut FriessDepartment of Surgery, Klinikum rechts der Isar, School of Medicine and Healthy, Technical University of Munich (TUM), Munich, Germany.
Ingrid HerrDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-2389-6300
Christoph W MichalskiDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Bo KongDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-5281-9603

Funding

China Scholarship CouncilDeutsche Forschungsgemeinschaft KO 4369/4-1Deutsche Forschungsgemeinschaft KO 4369/6-1Deutsche Krebshilfe 70113828Hans Beger Stiftung 17-02-2022Wilhelm Sander-Stiftung 2022.135.1
6 · The paper itself

Abstract

The ARP2/3 complex, which orchestrates actin cytoskeleton organization and lamellipodia formation, has been implicated in the initiation of pancreatic ductal adenocarcinoma (PDAC). This study aims to clarify its impact on the activity of cancer-associated fibroblasts (CAFs), key players in PDAC progression, and patient outcomes. Early pancreatic carcinogenesis was modeled in p48

Indexed as

Actin-Related Protein 2-3 ComplexCancer-Associated FibroblastsCarcinoma, Pancreatic DuctalAnimalsCarcinogenesisCell MovementCeruletideGene Expression ProfilingHumansMiceMyofibroblastsPancreatic Stellate CellsPrognosisTumor MicroenvironmentActin-Related Protein 2-3 ComplexCeruletidecancer‐associated fibroblastsmyCAFspancreatic carcinogenesistranscriptional signaturetransforming growth factor β

Identifiers

PMID39472297
PMCPMC11737003

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.