Evidence map›Paper›PMID 39472759›Full record

GuidelineNature medicine2024

Recommendations to promote equity, diversity and inclusion in decentralized clinical trials.

Olalekan Lee Aiyegbusi, Samantha Cruz Rivera, Paul Kamudoni, Nicola Anderson, Philip Collis, Alastair K Denniston, Rosie Harding, Sarah E Hughes, Kamlesh Khunti, Dipak Kotecha and 11 more

Abstract readGuidelineReview
PubMed Publisher
In one paragraph

Guideline in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Trial
  2. Article
  3. AI-based augmentation of oncology clinical trials.Nature reviews. Clinical oncology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Assessing the assessment: a scoping review of the mode of patient-reported outcome assessment in solid cancer clinical trials.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Olalekan Lee AiyegbusiCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. o.l.aiyegbusi@bham.ac.uk.ORCID http://orcid.org/0000-0001-9122-8251
Samantha Cruz RiveraCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Paul KamudoniMerck, Darmstadt, Germany.
Nicola AndersonCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Philip CollisCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Alastair K DennistonNational Institute for Health and Care Research Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-7849-0087
Rosie HardingBirmingham Law School, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-3063-3525
Sarah E HughesCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0001-5656-1198
Kamlesh KhuntiCentre for Ethnic Health Research, National Institute for Health and Care Research Applied Research Collaboration East Midlands, University of Leicester, Leicester, UK.
Dipak KotechaNational Institute for Health and Care Research Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-2570-9812
Harlan KrumholzYale School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2046-127X
Xiaoxuan LiuNational Institute for Health and Care Research Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-1286-0038
Christel McMullanCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-0878-1513
Barbara Molony-OatesHealth Research Authority, London, UK.ORCID http://orcid.org/0000-0002-2979-5578
Joao MonteiroNature Medicine, New York, NY, USA.
Puja MylesClinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, London, UK.
Khadija Rerhou RantellMedicines and Healthcare products Regulatory Agency, London, UK.
Katherine SoltysHealth Canada, Ottawa, Ontario, Canada.
Ravinder VerdiCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Roger WilsonCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Melanie J CalvertCentre for Patient Reported Outcomes Research, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-1856-837X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. Rapid advancements in digital technologies have supported the adoption of these trials. These innovations facilitate virtual interactions between clinical trial teams and participants by making it easier to collect, transfer and store electronic data. While some studies have demonstrated the potential for these approaches to reduce barriers to clinical trial participation, they are associated with several challenges that may create or worsen existing health inequalities and limit the generalizability of trial results. Here we review the potential for digitally enabled and decentralized clinical trials to enhance clinical trial participation in an equitable manner. We describe the key barriers individuals from underserved groups may face, and provide recommendations to promote equity, diversity and inclusion.

Indexed as

Health EquityClinical Trials as TopicCultural DiversityHumans

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.