Evidence map›Paper›PMID 39472899›Full record

ArticleBMC musculoskeletal disorders2024

Association of hemoglobin-to-red blood cell distribution width ratio and bone mineral density in older adults.

Yongchun Xiao, Huawen Pan, Ruihua Huang, Ping Wu, Cheng Peng, Jianxian Luo, Jianxiong Wu, Zhifeng Wang, Hongsheng Lin, Junze Liang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongchun Xiao *Department of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Huawen Pan *Department of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Ruihua Huang *MOE Key Laboratory of Tumor Molecular Biology and State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Life Science and Technology, Jinan University, Guangzhou, 510630, China.
Ping WuDepartment of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Cheng PengDepartment of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Jianxian LuoDepartment of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Jianxiong WuDepartment of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Zhifeng WangDepartment of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Hongsheng LinDepartment of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. tlinhsh@jnu.edu.cn.
Junze LiangMOE Key Laboratory of Tumor Molecular Biology and State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Life Science and Technology, Jinan University, Guangzhou, 510630, China. ljzlxylzhyl@gmail.com.
Zhisheng JiDepartment of Orthopedics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. tzhishengji@jnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemoglobin-to-Red Cell Distribution Width Ratio (HRR) represents novel prognostic markers for diseases. However, there remains a lack of systematic research into the relationship between HRR and Bone Mineral Density (BMD) or osteoporosis in older adults.

methodsThis study utilized information from the NHANES database, selecting individuals over 50 years of age with complete femoral DXA scans and full blood counts. The relationship between HRR and femoral BMD was investigated using weighted linear models and restricted cubic spline (RCS) models. Moreover, the association between HRR and osteoporosis was further explored using logistic regression models and RCS models, with subgroup analysis conducted to test the robustness of the results.

resultsThis study included a total of 7,149 participants, and the BMD of the group with higher HRR was significantly greater than that of the group with lower HRR. Weighted linear regression analysis found a linear positive correlation between HRR and femoral BMD. When HRR was converted from a continuous variable to a categorical variable, this relationship remained stable. In addition, multivariate logistic regression analysis showed that for each 1-unit increase in HRR, the prevalence of osteoporosis significantly decreased (OR = 0.25, 95% CI: 0.12-0.51), further confirming the findings of this study. Subgroup analysis showed that this association was not significantly affected by confounding factors across different populations.

conclusionHRR may serve as one of the potential indicators for evaluating BMD and assessing the prevalence of osteoporosis in the elderly. Elevating HRR levels may play a crucial role in the prevention and slowing of osteoporosis progression.

Indexed as

Absorptiometry, PhotonBone DensityHemoglobinsOsteoporosisAgedAged, 80 and overCross-Sectional StudiesErythrocyte IndicesFemaleFemurHumansMaleMiddle AgedNutrition SurveysHemoglobinsBone Mineral DensityHemoglobinHemoglobin-to-red cell distribution width ratioOsteoporosisRed cell distribution width

Identifiers

PMID39472899
PMCPMC11523879

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.