Evidence map›Paper›PMID 39472918›Full record

ArticleBMC musculoskeletal disorders2024

The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis.

Ghada A Elshaarawy, Iman I Salama, Somaia I Salama, Amany H Abdelrahman, Mirhane Hassan, Eman Eissa, Sherif Ismail, Sherif E Eldeeb, Doaa E Ahmed, Hazem Elhariri and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ghada A ElshaarawyCommunity Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt. dr.ghada237@gmail.com.ORCID http://orcid.org/0000-0001-7165-0594
Iman I SalamaCommunity Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Somaia I SalamaCommunity Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Amany H AbdelrahmanClinical & Chemical Pathology Department, Medical Research and Clinical Studies Institute,, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Mirhane HassanClinical & Chemical Pathology Department, Medical Research and Clinical Studies Institute,, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Eman EissaImmunogenetics Department, Human Genetics and Genome Research Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Sherif IsmailInternal Medicine Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Sherif E EldeebCommunity Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Doaa E AhmedCommunity Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Hazem ElhaririCommunity Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Rasmia ElgoharyRheumatology and Immunology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, El-Maniel, P.O. 11562, Cairo, Egypt.
Aida M AbdelmohsenCommunity Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Walaa A FouadCommunity Medicine Research Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
Hala M RaslanInternal Medicine Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.

Funding

National Research Centre, Egypt 12060149
6 · The paper itself

Abstract

Knee osteoarthritis (KOA) is an important cause of disability in the world and it denotes a public health defiance of the upcoming years.Aim To examine the connection between ADAMTS14 gene rs4747096 polymorphism and KOA and to assess risk factors associated with KOA.Methods A case control study was conducted on 158 patients with KOA and 120 controls with comparable age and sex randomly recruited from National Research Centre employees. All participants were subjected to full history taking, assessment of KOA severity using WOMAC scoring system, and thorough clinical examination. Blood sample was collected for detection of ADAMTS14/rs4747096 gene polymorphism.Results The frequency of ADAMTS14 gene rs4747096 genotypes among patients with KOA was 73.5% for AA, 25.7% for AG, and 0.7% for GG compared to controls 963%, 31.3%, and 5.6% respectively and the frequency of alleles among patients was 86.4% for A and 78.7% for G compared to controls (78.7% and 21.3% respectively, P < 0.05. The study found that the median levels of total WOMAC score and its domains were significantly higher among KOA patients than controls. The logistic regression analysis revealed that age ≥ 50 years, BMI ≥ 35, and long standing at work were predictive factors for KOA (P < 0.05). Regarding different genetic patterns, only the A recessive pattern of inheritance was found to be a predictive risk factor for KOA.Conclusion For ADAMTS14 rs4747096 genotype, the AA and AG genotypes significantly increased the risk of KOA. The recessive pattern of inheritance, older age, morbid obesity, and prolonged standing at work were the predictive risk factors for KOA. Further studies with larger sample size are encouraged to investigate the mechanism by which this genotype can affect the development of KOA.

Indexed as

Genetic Predisposition to DiseaseOsteoarthritis, KneePolymorphism, Single NucleotideADAMTS ProteinsAdultAgedCase-Control StudiesFemaleGene FrequencyGenotypeHumansMaleMiddle AgedRisk FactorsSeverity of Illness IndexADAMTS14 protein, humanADAMTS ProteinsADAMTS14 gene rs4747096AllelesAnd WOMACGenotypesKOA

Identifiers

PMID39472918
PMCPMC11523595

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.