Evidence map›Paper›PMID 39473183›Full record

ReviewHGG advances2025

Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.

Hridya Rao, Margaret C Weiss, Jee Young Moon, Krista M Perreira, Martha L Daviglus, Robert Kaplan, Kari E North, Maria Argos, Lindsay Fernández-Rhodes, Tamar Sofer

Abstract readReview
In one paragraph

Review in HGG advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Novel genetic profile linked to cognitive decline in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. APOE and plasma AD biomarkers: The role of genetic ancestry in Hispanics/Latinos.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Estimating population structure using epigenome-wide methylation data.medRxiv : the preprint server for health sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hridya RaoDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.
Margaret C WeissDepartment of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, USA.
Jee Young MoonDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Krista M PerreiraDepartment of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Martha L DaviglusInstitute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.
Robert KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Maria ArgosDepartment of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, USA; Department of Environmental Health, School of Public Health, Boston University, Boston, MA, USA.
Lindsay Fernández-RhodesDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.
Tamar SoferCardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: tsofer@bidmc.harvard.edu.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3M
Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9M
PAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5M
Gene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9M
Hispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8M
Integrative Approaches to Identifying Function and Clinical Significance of Adiposity Susceptibility GenesR01DK122503 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Anne Justice, Ching-Ti Liu · 2020 to 2026
$4.5M
Using polygenic risk scores and omics to study how suboptimal sleep accelerates cognitive aging in diverse populationsR01AG080598 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Tamar Sofer · 2023 to 2026
$3.6M
NRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4M
Leveraging omics data to understand sleep health and its consequences among diverse Hispanics/LatinosR01HL161012 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Tamar Sofer · 2022 to 2026
$3.2M
NCATS NIH HHS TL1 TR002016NCATS NIH HHS UL1 TR002014NHGRI NIH HHS HHSN268201300003CNHGRI NIH HHS R01 HG010297NHLBI NIH HHS HHSN268201300001CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS HHSN268201300004CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL161012NHLBI NIH HHS R01 HL163262NIA NIH HHS R01 AG080598NICHD NIH HHS R01 HD057194NIDDK NIH HHS R01 DK122503NIEHS NIH HHS F30 ES033510NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.

Indexed as

Genetic ResearchHispanic or LatinoAdultFemaleHumansLongitudinal StudiesMaleRetrospective StudiesUnited States

Identifiers

PMID39473183
PMCPMC11754138

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.