Evidence map›Paper›PMID 39473248›Full record

ReviewCNS & neurological disorders drug targets2025

Proposed Hypothesis of TWEAK/Fn14 Receptor Modulation in Autism Spectrum Disorder.

Heena Khan, Vivek Rihal, Amarjot Kaur, Thakur Gurjeet Singh

Abstract readReview
PubMed Publisher
In one paragraph

Review in CNS & neurological disorders drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Heena KhanChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.
Vivek RihalChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.
Amarjot KaurChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.
Thakur Gurjeet SinghChitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a complex, multiple etiology that is marked by impaired social interaction, communication, and repetitive behaviour. There is presently no pharmaceutical treatment for the core symptoms of ASD, even though the prevalence of ASD is increasing worldwide. Treatment of autism spectrum disorder involves the interaction of numerous signalling pathways, such as the Wnt/beta-catenin pathway, probiotics and kynurenine pathway, PPAR pathway, PI3K-AKT-mTOR pathway, Hedgehog signaling pathway, etc. The scientific literature has revealed TWEAK/Fn14 to not be explored in the autism spectrum disorder.

Indexed as

Autism Spectrum DisorderCytokine TWEAKTWEAK ReceptorAnimalsBlood-Brain BarrierHumansSignal TransductionCytokine TWEAKTNFRSF12A protein, humanTNFSF12 protein, humanTWEAK Receptoraurintricarboxylic acidautismAutism spectrum disorderHedgehog signaling pathwaymitochondrial malfunctiontumour necrosis factor.

Identifiers

PMID39473248

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.