ArticleiScience2024
West Nile virus can be transmitted within mosquito populations through infectious mosquito excreta.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Convergent enrichment of Gammaproteobacteria along Aedes aegypti development across different breeding sites.Animal microbiome · 2026Article
- Detection and genetic characterization of Tembusu virus and other flaviviruses from mosquitoes in Lao PDR.PloS one · 2026Article
- Tracking the urban spread of Usutu virus in southern France: Detection across biological and environmental matrices.PLoS neglected tropical diseases · 2025Article
- Vertical transmission in field-caught mosquitoes identifies a mechanism for the establishment of Usutu virus in a temperate country.Scientific reports · 2025Article
- The Spread of the Mosquito-Transmitted West Nile Virus in North America and Europe.Microbial biotechnology · 2025Review
- Assessment of flavivirus RNA stability and infectivity in various water environments.Tropical medicine and health · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the transmission routes of arboviruses is key to determining their epidemiology. Here, we tested whether West Nile viruses (WNVs) are transmitted through mosquito excreta. First, we observed a high concentration of infectious units per excreta, although viruses were short lived. Second, we showed that virion excretion starts early after oral infection and remains constant for a long period, regardless of mosquito infection level. These results highlight the infectiousness of excreta from infected mosquitoes. Third, we found that both larvae and pupae were susceptible to infection, while pupae were highly permissive. Fourth, we established the proof-of-concept that immature mosquitoes can be infected by infectious excreta, demonstrating an excreta-mediated mode of transmission. Finally, by mathematically modeling excreta-mediated transmission in the field, we demonstrated that WNV can be transmitted within mosquito populations. Our study uncovers a route of transmission for mosquito-borne arboviruses, unveiling mechanisms of viral maintenance in mosquito reservoirs.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.