Evidence map›Paper›PMID 39474044›Full record

ArticleBrain communications2024

Clinical parameters affect the structure and function of superficial pyramidal neurons in the adult human neocortex.

Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Hanna Hemeling, Phyllis Stöhr, Jürgen Beck, Andreas Vlachos

Abstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The Freiburg framework for multimodalFrontiers in synaptic neuroscience · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maximilian LenzDepartment of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.ORCID https://orcid.org/0000-0003-3147-4949
Pia KruseDepartment of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.ORCID https://orcid.org/0000-0002-1742-1608
Amelie EichlerDepartment of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.ORCID https://orcid.org/0000-0001-7990-654X
Jakob StraehleDepartment of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Hanna HemelingDepartment of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.ORCID https://orcid.org/0009-0009-2741-7774
Phyllis StöhrDepartment of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Jürgen BeckDepartment of Neurosurgery, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Andreas VlachosDepartment of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interplay between neuronal structure and function underpins the dynamic nature of neocortical networks. Despite extensive studies in animal models, our understanding of structure-function interrelations in the adult human brain remains incomplete. Recent methodological advances have facilitated the functional analysis of individual neurons within the human neocortex, providing a new understanding of fundamental brain processes. However, the factors contributing to patient-specific neuronal properties have not been thoroughly explored. In this observational study, we investigated the structural and functional variability of superficial pyramidal neurons in the adult human neocortex. Using whole-cell patch-clamp recordings and

Indexed as

excitatory synapseshuman dendritic spineshuman neocortex

Identifiers

PMID39474044
PMCPMC11518857

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.