ReviewiScience2024
Rap1b: A cytoskeletal regulator Advantageous to viral infection.
Review in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Multilabel prediction of virus target proteins via multimodal graph representation learning.PLoS computational biology · 2026Article
- Discordant effects of maternal age on the human MII oocyte transcriptome.Molecular human reproduction · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RAS-like small GTP-binding protein 1b (Rap1b) is a small GTPase involved in numerous deformation-mediated physiological processes, including viral infection, through cytoskeleton regulation on the premise of dynamic changes in the loading state of GTP or GDP. Previous studies have mainly focused on Rap1b's roles in tumor metastasis and platelet hemostasis due to their significant cytoskeleton rearrangement. The complexity of Rap1b and cytoskeleton functions has limited research on their role in viral infections, and the molecular mechanisms for drug and vaccine development targeting Rap1b remain unclear. Here, we reviewed the mechanisms used by Rap1b to sustain cancer growth through the cytoskeleton and analyzed the role of Rap1b protein in the regulation of the cytoskeleton, as well as its use to promote replication in response to viral invasion, highlighting that it may be a potential target for development of antiviral strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.